Deployment of metabolic heat rate based soft sensor for estimation and control of specific growth rate in glycoengineered Pichia pastoris for human interferon alpha 2b production

Autor:	Pavan Allampalli, Sivakumar Rathinavelu, Naresh Mohan, Senthilkumar Sivaprakasam
Rok vydání:	2022
Předmět:	Hot Temperature Bioreactors Methanol Fermentation Humans Bioengineering General Medicine Interferon alpha-2 Applied Microbiology and Biotechnology Pichia Recombinant Proteins Biotechnology
Zdroj:	Journal of biotechnology. 359
ISSN:	1873-4863
Popis:	Lack of appropriate process models, reliable online sensors, and process variability in bioprocess systems are poising challenges in real-time monitoring and control of critical process parameters (CPPs). This present investigation deals with the development of a non-invasive soft sensor by utilizing metabolic heat rate as input signal for online estimation of specific growth rate (μ
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0766f3207352b68d32019a3501bd8691 https://pubmed.ncbi.nlm.nih.gov/36252874 Zobrazit plný text záznamu Full Text from ScienceDirect