Double-Blind Crossover Trial Comparing Systemic Chromone-Carboxylic Acid with Placebo in Patients with Atopic Dermatitis
| Autor: | PoulØlholm Larsen, Gunnar Kavli |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Immunology Placebo Dermatitis Atopic Placebos Double blind Double-Blind Method Internal medicine medicine Humans Immunology and Allergy In patient Dyspepsia Clinical Trials as Topic Adult patients business.industry Pruritus Atopic dermatitis medicine.disease Crossover study Dermatology Treatment period Chromones Patient Compliance Female business |
| Zdroj: | Allergy. 36:597-600 |
| ISSN: | 1398-9995 0105-4538 |
| Popis: | 35 adult patients with atopic dermatitis were included in a double-blind crossover trial comparing chromone-2-carboxylic acid, FPL 57787 18 mg × 4, with placebo. Each treatment period lasted for 6 weeks with clinical assessment every 3 weeks, 28 patients completed 3 weeks of each period. Significant differences at the 5 % level in favour of FPL 57787 were seen in the group starting on placebo. 17 patients completed the study. After 6 weeks there were no significant differences. 10 patients experienced dyspeptic side-effects. Further studies are warranted on clearly allergic sub-groups of atopic dermatitis patients. |
| Databáze: | OpenAIRE |
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