Endolysosomal Mesoporous Silica Nanoparticle Trafficking along Microtubular Highways

Autor:	Achraf Noureddine, Michael L. Paffett, Stefan Franco, Alfonso E. Chan, Sandeep Pallikkuth, Keith Lidke, Rita E. Serda
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	mitosis Pharmaceutical Science cytokinesis Article mitotic nanotube microtubules RS1-441 Flemming body tunneling nanotube Pharmacy and materia medica midbody super-resolution microscopy scanning electron microscopy mesoporous silica nanoparticle hyperploid cell
Zdroj:	Pharmaceutics, Vol 14, Iss 56, p 56 (2022) Pharmaceutics Pharmaceutics; Volume 14; Issue 1; Pages: 56
ISSN:	1999-4923
Popis:	This study examines intra- and intercellular trafficking of mesoporous silica nanoparticles along microtubular highways, with an emphasis on intercellular bridges connecting interphase and telophase cells. The study of nanoparticle trafficking within and between cells during all phases of the cell cycle is relevant to payload destination and dilution, and impacts delivery of therapeutic or diagnostic agents. Super-resolution stochastic optical reconstruction and sub-airy unit image acquisition, the latter combined with Huygens deconvolution microscopy, enable single nanoparticle and microtubule resolution. Combined structural and functional data provide enhanced details on biological processes, with an example of mitotic inheritance during cancer cell trivision.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0762fea645734f8f2f78c73b1f923748 https://www.mdpi.com/1999-4923/14/1/56 Zobrazit plný text záznamu