Cryptic ins(4;11)(q21;q23q23) detected by fluorescence in situ hybridization: a variant of t(4;11)(q21;q23) in an infant with a precursor B-cell acute lymphoblastic leukemia report of a second case
| Autor: | C.A. Tirado, A.M. Meloni-Ehrig, T. Edwards, J. Scheerle, K. Burks, C. Repetti, N.C. Christacos, J.C. Kelly, J. Greenberg, C. Murphy, C.D. Croft, D. Heritage, P.N. Mowrey |
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| Rok vydání: | 2006 |
| Předmět: |
Cancer Research
Biology Translocation Genetic hemic and lymphatic diseases Genetics medicine Humans Molecular Biology Metaphase In Situ Hybridization Fluorescence medicine.diagnostic_test Chromosomes Human Pair 11 Karyotype B-cell acute lymphoblastic leukemia Histone-Lysine N-Methyltransferase Precursor Cell Lymphoblastic Leukemia-Lymphoma Molecular biology Burkitt Lymphoma Chromosome Banding Mutagenesis Insertional Chromosome 4 Child Preschool Karyotyping Myeloid-Lymphoid Leukemia Protein Interphase Female Isochromosome 7q Chromosomes Human Pair 4 Fluorescence in situ hybridization |
| Zdroj: | Cancer genetics and cytogenetics. 174(2) |
| ISSN: | 0165-4608 |
| Popis: | We report the chromosomal findings in a 4-year-old female with precursor B-cell acute lymphoblastic leukemia (ALL). The diagnostic karyotype showed an isochromosome 7q, i(7)(q10), as well as questionable rearrangements on 9p and 11q. Fluorescence in situ hybridization (FISH) studies on both interphase and metaphase cells using the MLL "break-apart" and the centromeric chromosome 4 probes were instrumental in the characterization of an MLL gene rearrangement, which was cryptic by conventional cytogenetic analysis. Specifically, the FISH pattern was consistent with an insertion of the 5' region of the MLL gene into chromosome 4 at band q21, most likely a variant t(4;11)(q21;q23). This is the second case of FISH detection of an ins(4;11) in ALL. Our case exemplifies the importance of FISH in the further characterization of precursor B-cell ALL cases without any apparent prognostically significant chromosomal abnormalities. |
| Databáze: | OpenAIRE |
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