Regulation of GPCR-mediated smooth muscle contraction: implications for asthma and pulmonary hypertension
Autor: | Oluwaseun O. Ojo, David Wright, A Sikarwar, Samarth Tripathi, Jose F. Perez-Zoghbi, Dedmer Schaafsma, K T Santosh, Jeremy P.T. Ward, Nneka Ifeoma Irechukwu |
---|---|
Rok vydání: | 2012 |
Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Myosin light-chain kinase Hypertension Pulmonary education Biology Muscle Smooth Vascular Receptors G-Protein-Coupled Internal medicine medicine Animals Humans Pharmacology (medical) Receptor Rho-associated protein kinase G protein-coupled receptor Biochemistry (medical) Muscle Smooth Smooth muscle contraction medicine.disease Pulmonary hypertension Asthma Endocrinology Calcium medicine.symptom Vascular smooth muscle contraction Neuroscience Muscle contraction Muscle Contraction |
Zdroj: | Pulmonary pharmacologytherapeutics. 26(1) |
ISSN: | 1522-9629 |
Popis: | Contractile G-protein-coupled receptors (GPCRs) have emerged as key regulators of smooth muscle contraction, both under healthy and diseased conditions. This brief review will discuss some key topics and novel insights regarding GPCR-mediated airway and vascular smooth muscle contraction as discussed at the 7th International Young Investigators' Symposium on Smooth Muscle (2011, Winnipeg, Manitoba, Canada) and will in particular focus on processes driving Ca(2+)-mobilization and -sensitization. |
Databáze: | OpenAIRE |
Externí odkaz: |