Behavioral analysis of the saccharin deprivation effect in rats
| Autor: | Anton Bespalov, Olga N Neznanova, Edwin Zvartau |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Drugs of abuse Time Factors media_common.quotation_subject Alcohol abuse Physiology Context (language use) Environment Choice Behavior Association Behavioral Neuroscience chemistry.chemical_compound Saccharin medicine Animals Rats Wistar Psychiatry media_common Analysis of Variance Behavior Animal Dose-Response Relationship Drug Addiction medicine.disease Privation Rats Behavioral analysis Phase duration chemistry Sweetening Agents Psychology Food Deprivation psychological phenomena and processes |
| Zdroj: | Behavioral neuroscience. 116(5) |
| ISSN: | 0735-7044 |
| Popis: | The deprivation effect (DE)--an increase in the level of free-choice consumption of alcohol after a period of forced abstinence--may reflect relapselike drinking and be relevant for modeling alcohol abuse. However, the behavioral mechanisms of the DE are unclear. In these experiments, rats had unlimited free-choice access to water and saccharin-containing solutions and underwent repeated episodes of saccharin deprivation. It was found that DE magnitude correlates positively with the deprivation phase duration, expression of the DE is highly context dependent, and the DE can be prevented by extinguishing response to the saccharin-associated stimuli. Thus, DE procedures may be useful for studying the effects of continued exposure to stimuli associated with various primary reinforcers such as drugs of abuse. |
| Databáze: | OpenAIRE |
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