Lipid Droplets in Cancer: Guardians of Fat in a Stressful World
| Autor: | Eva Jarc, Toni Petan, Maida Jusović |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
autophagy Cell Survival Lipolysis lipid droplets nutrient stress Pharmaceutical Science Review medicine.disease_cause fatty acids Analytical Chemistry Fats lcsh:QD241-441 03 medical and health sciences lcsh:Organic chemistry Neoplasms Lipid droplet Drug Discovery Organelle medicine lipase Animals Homeostasis Humans cancer oxidative stress lipophagy Physical and Theoretical Chemistry phospholipase Cell Proliferation Chemistry Organic Chemistry Autophagy Lipid metabolism lipotoxicity Lipid Metabolism Cell biology 030104 developmental biology Lipotoxicity Chemistry (miscellaneous) Membrane biogenesis Molecular Medicine lipids (amino acids peptides and proteins) Intracellular Oxidative stress |
| Zdroj: | Molecules, Vol 23, Iss 8, p 1941 (2018) Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry |
| ISSN: | 1420-3049 |
| Popis: | Cancer cells possess remarkable abilities to adapt to adverse environmental conditions. Their survival during severe nutrient and oxidative stress depends on their capacity to acquire extracellular lipids and the plasticity of their mechanisms for intracellular lipid synthesis, mobilisation, and recycling. Lipid droplets, cytosolic fat storage organelles present in most cells from yeast to men, are emerging as major regulators of lipid metabolism, trafficking, and signalling in various cells and tissues exposed to stress. Their biogenesis is induced by nutrient and oxidative stress and they accumulate in various cancers. Lipid droplets act as switches that coordinate lipid trafficking and consumption for different purposes in the cell, such as energy production, protection against oxidative stress or membrane biogenesis during rapid cell growth. They sequester toxic lipids, such as fatty acids, cholesterol and ceramides, thereby preventing lipotoxic cell damage and engage in a complex relationship with autophagy. Here, we focus on the emerging mechanisms of stress-induced lipid droplet biogenesis; their roles during nutrient, lipotoxic, and oxidative stress; and the relationship between lipid droplets and autophagy. The recently discovered principles of lipid droplet biology can improve our understanding of the mechanisms that govern cancer cell adaptability and resilience to stress. |
| Databáze: | OpenAIRE |
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