Patterns of Growth and Decline in Lung Function in Persistent Childhood Asthma
| Autor: | N F Adkinson, Anne L. Fuhlbrigge, Robert A. Wise, Robert C. Strunk, Scott T. Weiss, Hartmut Grasemann, Quan Lu, Gerard H. Koppelman, Alvin T. Kho, Dirkje S. Postma, Bryan R. Lajoie, Sunita Sharma, Ronina A. Covar, Paul V. Williams, Job Dekker, I Houston, Gaurav Jain, Kelan G. Tantisira, Michael J. McGeachie, Alice L. Sternberg, Judith M. Vonk, Stanley J. Szefler, Feng Guo, James Tonascia, Ye Zhan, Edwin K. Silverman, Peter J. Castaldi, Robert S. Zeiger, Xiaobo Zhou, Katherine P. Yates, Benjamin A. Raby, Amartya Sanyal, Damien C. Croteau-Chonka, M. L. Van Natta, John A. Stamatoyannopoulos, Kelly Hw, Michael H. Cho |
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| Přispěvatelé: | School of Biological Sciences, Lee Kong Chian School of Medicine (LKCMedicine), Groningen Research Institute for Asthma and COPD (GRIAC) |
| Rok vydání: | 2016 |
| Předmět: |
Male
Nedocromil Budesonide Pediatrics Anti-Inflammatory Agents Kaplan-Meier Estimate ADULTHOOD 0302 clinical medicine Risk Factors Forced Expiratory Volume ADOLESCENTS Longitudinal Studies 030212 general & internal medicine Young adult Child Lung POPULATION education.field_of_study medicine.diagnostic_test General Medicine Biological Sciences respiratory system Bronchodilator Agents Child Preschool Cohort Medicine Female medicine.drug Spirometry medicine.medical_specialty Adolescent National Health and Nutrition Examination Survey Population AIR-FLOW LIMITATION OBSTRUCTIVE PULMONARY-DISEASE Article Young Adult 03 medical and health sciences Sex Factors HYPERRESPONSIVENESS Administration Inhalation medicine Humans COHORT education Asthma business.industry MORTALITY medicine.disease respiratory tract diseases 030228 respiratory system RISK-FACTORS FOLLOW-UP business |
| Zdroj: | New England Journal of Medicine, 374(19), 1842-1852. MASSACHUSETTS MEDICAL SOC |
| ISSN: | 1533-4406 0028-4793 |
| DOI: | 10.1056/nejmoa1513737 |
| Popis: | BACKGROUND: Tracking longitudinal measurements of growth and decline in lung function in patients with persistent childhood asthma may reveal links between asthma and subsequent chronic airflow obstruction.METHODS: We classified children with asthma according to four characteristic patterns of lung-function growth and decline on the basis of graphs showing forced expiratory volume in 1 second (FEV1), representing spirometric measurements performed from childhood into adulthood. Risk factors associated with abnormal patterns were also examined. To define normal values, we used FEV1 values from participants in the National Health and Nutrition Examination Survey who did not have asthma.RESULTS: Of the 684 study participants, 170 (25%) had a normal pattern of lung-function growth without early decline, and 514 (75%) had abnormal patterns: 176 (26%) had reduced growth and an early decline, 160 (23%) had reduced growth only, and 178 (26%) had normal growth and an early decline. Lower baseline values for FEV1, smaller bronchodilator response, airway hyperresponsiveness at baseline, and male sex were associated with reduced growth (PCONCLUSIONS: Childhood impairment of lung function and male sex were the most significant predictors of abnormal longitudinal patterns of lung-function growth and decline. Children with persistent asthma and reduced growth of lung function are at increased risk for fixed airflow obstruction and possibly COPD in early adulthood. (Funded by the Parker B. Francis Foundation and others; ClinicalTrials.gov number, NCT00000575.). |
| Databáze: | OpenAIRE |
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