Escherichia coli: an old friend with new tidings
| Autor: | F. Baquero, Pilar Retamar, Emma Sáez-López, Jaime Bosch, Sara M. Soto, Jordi Vila, James R. Johnson, Thierry Naas, Ute Römling, M. Martínez-Medina, Christian G. Giske, Jesús Rodríguez-Baño, Ulrich Dobrindt, Alessandra Carattoli, Rafael Cantón |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Modern medicine Etiology Virulence Factors medicine.drug_class Epidemiology 030106 microbiology Antibiotics Virulence Disease Biology medicine.disease_cause Microbiology 03 medical and health sciences Antibiotic resistance Sepsis Drug Resistance Bacterial Aminoglycoside amoxicillin plus clavulanic acid antibiotic agent bacterial enzyme beta lactamase AmpC carbapenem derivative colistin extended spectrum beta lactamase fosfomycin fosfomycin trometamol pivmecillinam quinoline derived antiinfective agent temocillin tigecycline virulence factor antiinfective agent antibiotic resistance bacterial colonization bacterial genome bacterial strain bacterial virulence bacterium isolate biofilm carbapenemase producing Enterobacteriaceae Escherichia coli Escherichia coli infection extraintestinal pathogenic Escherichia coli health care cost human inflammatory bowel disease meta analysis (topic) multidrug resistance newborn sepsis nonhuman pathogenesis pathophysiology phenotypic plasticity plasmid randomized controlled trial (topic) Review urinary tract infection drug effects microbiology pathogenicity sepsis urinary tract infection Anti-Bacterial Agents Escherichia coli Infections Humans Urinary Tract Infections medicine Colonization Epidemiologia Resistència als medicaments Extraintestinal Pathogenic Escherichia coli Public health Salut pública Anti-Bacterial Agents Infectious Diseases Escheríchia coli Etiologia Drug resistance |
| Zdroj: | Dipòsit Digital de la UB Universidad de Barcelona Europe PubMed Central Recercat. Dipósit de la Recerca de Catalunya instname |
| Popis: | Escherichia coli is one of the most-studied microorganisms worldwide but its characteristics are continually changing. Extraintestinal E. coli infections, such as urinary tract infections and neonatal sepsis, represent a huge public health problem. They are caused mainly by specialized extraintestinal pathogenic E. coli (ExPEC) strains that can innocuously colonize human hosts but can also cause disease upon entering a normally sterile body site. The virulence capability of such strains is determined by a combination of distinctive accessory traits, called virulence factors, in conjunction with their distinctive phylogenetic background. It is conceivable that by developing interventions against the most successful ExPEC lineages or their key virulence/colonization factors the associated burden of disease and health care costs could foreseeably be reduced in the future. On the other hand, one important problem worldwide is the increase of antimicrobial resistance shown by bacteria. As underscored in the last WHO global report, within a wide range of infectious agents including E. coli, antimicrobial resistance has reached an extremely worrisome situation that 'threatens the achievements of modern medicine'. In the present review, an update of the knowledge about the pathogenicity, antimicrobial resistance and clinical aspects of this 'old friend' was presented. |
| Databáze: | OpenAIRE |
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