Regression of Chronic L -NAME-Treatment-induced Left Ventricular Hypertrophy: Effect of Captopril
| Autor: | Fedor Šimko, Václav Pelouch, Ol»ga Pecháňová, Iveta Bernatova |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
medicine.medical_specialty Captopril Heart Ventricles Remission Spontaneous Muscle Proteins Angiotensin-Converting Enzyme Inhibitors Nitric Oxide Left ventricular hypertrophy Muscle hypertrophy Nitric oxide Renin-Angiotensin System chemistry.chemical_compound Internal medicine medicine Animals Rats Wistar LV hypertrophy Molecular Biology Ventricular Remodeling business.industry Body Weight DNA Organ Size Protein composition medicine.disease Rats NG-Nitroarginine Methyl Ester Endocrinology chemistry Hypertension Arginine methyl ester RNA Hypertrophy Left Ventricular Collagen Nitric Oxide Synthase Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Journal of Molecular and Cellular Cardiology. 32:177-185 |
| ISSN: | 0022-2828 |
| DOI: | 10.1006/jmcc.1999.1071 |
| Popis: | Long-term administration of N G -nitro- L -arginine methyl ester ( L -NAME) induces development of NO-deficient hypertension and left ventricular (LV) hypertrophy. In this work, we examined the effect of spontaneous and captopril-induced recovery on LV hypertrophy and protein composition in rats with developed L -NAME-induced hypertension. Four groups of rats were investigated: control L -NAME 40 mg/kg/day for 4 weeks ( L -NAME) L -NAME 40 mg/kg/day for 4 weeks followed by 3-week spontaneous recovery ( L -NAME+R) L -NAME 40 mg/kg/day for 4 weeks followed by 3 weeks of captopril treatment at a dose of 100 mg/kg/day ( L -NAME+C). LV hypertrophy in the L -NAME group was associated with an increase in content and concentration of left ventricular DNA and RNA, concentration of metabolic proteins (MP) and soluble collagenous proteins (SCP). Spontaneous recovery period reduced the hypertension, without regression of LV hypertrophy. Left ventricular DNA and RNA content were increased in the L -NAME+R group. In this group, concentrations of MP, contractile proteins (CP), and collagenous proteins did not differ from those in the L -NAME group. Captopril treatment caused total regression of hypertension and LV hypertrophy and decreased both content and concentration of DNA and RNA, as well as the contents of MP, CP and SCP v the L -NAME group. However, after captopril treatment, concentration of collagenous and non-collagenous protein fractions remained increased v control. We conclude that spontaneous regression of L -NAME-induced hypertension is not associated with regression of LV hypertrophy. LV hypertrophy was regressed only in captopril-treated animals. |
| Databáze: | OpenAIRE |
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