Can we rely on procalcitonin in the diagnosis of late onset neonatal sepsis?
| Autor: | R Agarwal, S Krishnamoorthy, N Athiraman, M Guy |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test biology Neonatal sepsis business.industry C-reactive protein Obstetrics and Gynecology Late onset General Medicine bacterial infections and mycoses medicine.disease Gastroenterology Procalcitonin Sepsis True negative Raised CRP Internal medicine parasitic diseases Pediatrics Perinatology and Child Health Immunology biology.protein Medicine Blood culture business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Archives of Disease in Childhood - Fetal and Neonatal Edition. 96:Fa40-Fa40 |
| ISSN: | 1468-2052 1359-2998 |
| Popis: | Aims: Methods: Infants ≥48 hours old and being investigated for LONS were recruited after informed consent. The sepsis episodes were categorised into 3 groups: True positive, True negative and Possible sepsis on the basis of clinical symptoms, results from blood culture or other sterile body fluids and raised CRP or thrombocytopenia. Results: A total of 219 sepsis episodes in 121 infants were evaluated. There were 79(36%) true positive, 68(31%) possible sepsis and 71(33%) true negative episodes of sepsis. The sensitivity and specificity were calculated for true positive versus true negative episodes; and the cut-off used for CRP and procalcitonin was 10 and 0.5 respectively. The sensitivity of procalcitonin and CRP was 68% and 56% respectively whereas the specificity was 60% and 85%. Table Conclusion: Procalcitonin is a useful marker of LONS. In this study, PCT is more sensitive but less specific than CRP in the diagnosis of late onset neonatal sepsis. PCT could be used as a useful adjuvant to CRP in the evaluation of late onset neonatal sepsis. |
| Databáze: | OpenAIRE |
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