Characterization of de novo diffuse large B-cell lymphoma with a translocation of c-myc and immunoglobulin genes
| Autor: | Tetsuo Kuze, Masafumi Abe, Ako Kikuchi, Shigeo Nakamura, Kiyoshi Ando, Yoshikazu Sasaki, Naoya Nakamura, Takashi Akasaka, Hitoshi Ohno, Koichi Ohshima |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Cancer Research Genotype Genes myc Immunoglobulin Variable Region Chromosomal translocation medicine.disease_cause Translocation Genetic Immunophenotyping immune system diseases hemic and lymphatic diseases medicine Humans neoplasms Aged Aged 80 and over Mutation Genes Immunoglobulin biology Chemistry Germinal center Hematology Middle Aged medicine.disease BCL6 Immunohistochemistry Molecular biology Lymphoma DNA-Binding Proteins Oncology Proto-Oncogene Proteins c-bcl-6 biology.protein Female Neprilysin Lymphoma Large B-Cell Diffuse Antibody Immunoglobulin Heavy Chains Diffuse large B-cell lymphoma |
| Zdroj: | Leukemia Research. 32:1176-1182 |
| ISSN: | 0145-2126 |
| DOI: | 10.1016/j.leukres.2007.10.006 |
| Popis: | The characteristics of de novo diffuse large B-cell lymphoma (DLBCL) with translocation of c- myc and immunoglobulin ( Ig ) genes (c- myc / Ig DLBCL), were investigated in 13 cases of c- myc / Ig DLBCL. Immunohistochemistry revealed five cases were positive for CD10 and BCL6 expression (CD10 + /BCL6 + ), five cases of CD10 − /BCL6 + /MUM1 − , one case of CD10 − /BCL6 + /MUM1 + and two cases of CD10 − /BCL6 − /MUM1 + expression, indicating 10 cases of germinal center B-cell DLBCL and three cases of non-germinal center B-cell DLBCL. Ongoing mutation of the Ig heavy chain gene variable region ( IgH-V ) was found in two cases with CD10 and BCL6 expression and one case showing CD10 − /BCL6 + /MUM1 − expression. These three cases of ongoing mutation of the IgH-V gene did not express BCL2, unlike those without ongoing mutation. These results suggest a heterogeneous immunophenotype and genotype for c- myc / Ig DLBCL, with CD10 − /BCL6 + /MUM1 − cases the most frequent. |
| Databáze: | OpenAIRE |
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