Pancreaticoduodenectomy for the Management of Pancreatic or Duodenal Metastases from Primary Sarcoma
| Autor: | Jeremy R Huddy, Mikael H. Sodergren, Khin Thway, Robin L. Jones, Satvinder Mudan, Jean Deguara |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty 040301 veterinary sciences medicine.medical_treatment Uterus Inferior vena cava Pancreaticoduodenectomy Metastasis 0403 veterinary science Young Adult 03 medical and health sciences 0302 clinical medicine Duodenal Neoplasms Humans Medicine Femur Aged business.industry Sarcoma 04 agricultural and veterinary sciences General Medicine Middle Aged medicine.disease Combined Modality Therapy Surgery Pancreatic Neoplasms medicine.anatomical_structure Oncology medicine.vein 030220 oncology & carcinogenesis Localized disease Female business Pancreas |
| Zdroj: | Anticancer Research. 38:4041-4046 |
| ISSN: | 1791-7530 0250-7005 |
| Popis: | Background/aim Sarcomas are rare and heterogeneous solid tumours of mesenchymal origin and frequently have an aggressive course. The mainstay of management for localized disease is surgical excision. Following excision there is approximately 30-50% risk of developing distant metastases. The role of pancreatic resection for metastatic sarcoma is unclear. Therefore, the aim of this study was to asses the outcome of patients with pancreatic metastases of sarcoma treated with surgical resection. Patients and methods A retrospective analysis of a prospectively maintained single-surgeon, single-centre database was undertaken. Seven patients were identified who underwent pancreaticoduodenectomy for the management of metastatic disease from sarcoma between 2006-2016. Results The median age was 59 (range=19-73) years, and there were six females and one male. The primary sites included the uterus, broad ligament, femur and inferior vena cava. One patient died in the early postoperative period. The remaining six patients developed further recurrent disease, with a median disease-free interval of 11 (range=4-27) months and median overall survival of 21 months (range=4 days to 86 months). Conclusion To our knowledge, this is the largest series of patients with pancreatic metastases of sarcoma treated with surgical resection. Despite optimal resection with R0 margins, in the absence of effective adjuvant systemic therapies, the benefit of such an approach in metastatic disease remains unclear. |
| Databáze: | OpenAIRE |
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