Impact of type 2 diabetes on nitric oxide and adrenergic modulation of myocardial perfusion

Autor: Ole Schmitz, Mette Madsen, Hans Erik Bøtker, Hanne Maare Søndergaard, Niels H. Buus, Torsten Toftegaard Nielsen, Morten Bøttcher
Jazyk: angličtina
Rok vydání: 2007
Předmět:
Male
Nitric Oxide/antagonists & inhibitors
Adenosine
Sympathetic Nervous System
Endocrinology
Diabetes and Metabolism
Vasodilator Agents
Adrenergic alpha-Antagonists/pharmacology
Blood Pressure
Type 2 diabetes
Phentolamine/pharmacology
chemistry.chemical_compound
Heart Rate
Medicine
Enzyme Inhibitors
Blood Pressure/physiology
Enzyme Inhibitors/pharmacology
Middle Aged
medicine.anatomical_structure
NG-Nitroarginine Methyl Ester
Female
Coronary Circulation/drug effects
Perfusion
Heart Rate/physiology
medicine.drug
medicine.medical_specialty
Nitric Oxide Synthase/antagonists & inhibitors
Hyperemia
Nitric Oxide
Nitric oxide
Phentolamine
Sympathetic Nervous System/physiology
Internal medicine
Coronary Circulation
Internal Medicine
Humans
NG-Nitroarginine Methyl Ester/pharmacology
Vasodilator Agents/pharmacology
Diabetes Mellitus
Type 2/physiopathology
Adrenergic alpha-Antagonists
Autonomic nerve
business.industry
medicine.disease
Blockade
Endocrinology
chemistry
Diabetes Mellitus
Type 2
Vascular resistance
Vascular Resistance
Vascular Resistance/physiology
Nitric Oxide Synthase
business
Adenosine/antagonists & inhibitors
Zdroj: Madsen, M M, Søndergaard, H S, Bøttcher, M, Buus, N H, Schmitz, O, Bøtker, H E & Nielsen, T T 2007, ' Impact of type 2 diabetes on nitric oxide and adrenergic modulation of myocardial perfusion ', Diabetes, vol. 56(2), pp. 468-75 .
Madsen, M M, Søndergaard, H M, Bøttcher, M, Buus, N H, Schmitz, O, Bøtker, H E & Toftegaard-Nielsen, T 2007, ' Impact of type 2 diabetes on nitric oxide and adrenergic modulation of myocardial perfusion ', Diabetes, vol. 56, no. 2, pp. 468-475 . https://doi.org/10.2337/db06-0635
Aarhus University
Madsen, M M, Søndergaard, H M, Bøttcher, M, Buus, N H, Schmitz, O, Bøtker, H E & Nielsen, T T 2007, ' Impact of type 2 diabetes on nitric oxide and adrenergic modulation of myocardial perfusion ', Diabetes, vol. 56, no. 2, pp. 468-75 . https://doi.org/10.2337/db06-0635
Madsen, M M, Søndergaard, H M, Bøttcher, M, Buus, N H, Schmitz, O, Bøtker, H E & Toftegaard-Nielsen, T 2007, ' Impact of type 2 diabetes on nitric oxide and adrenergic modulation of myocardial perfusion ', Diabetes .
DOI: 10.2337/db06-0635
Popis: Type 2 diabetic patients are characterized by a reduced adenosine-induced hyperemic myocardial perfusion, which may contribute to their increased cardiovascular morbidity. We hypothesized that the reduced hyperemia can be explained by functional changes in endothelial or autonomic nervous regulation. In 12 type 2 diabetic patients without signs of ischemic heart disease and 14 age-matched control subjects, myocardial perfusion was measured at rest, during adenosine, and during adenosine and α-receptor blockade (phentolamine) using positron emission tomography on two separate days: 1) with, and 2) without nitric oxide (NO) inhibition with NG-nitro-L-arginine methyl ester. Myocardial perfusion during adenosine was lower in type 2 diabetic patients compared with control subjects (P = 0.05). No significant effect of NO inhibition on myocardial perfusion during adenosine was found in any of the groups. In control subjects, α-receptor blockade increased hyperemic myocardial vascular resistance during NO inhibition, whereas no effect was observed in type 2 diabetic patients. At rest, a significant correlation was observed between rate-pressure product and myocardial perfusion in control subjects. NO inhibition and type 2 diabetes abolished this correlation. Endothelial and cardiac autonomic nerve function seems to play only a minimal role in the reduced hyperemic myocardial perfusion in type 2 diabetic patients. However, the linear correlation between resting perfusion and cardiac work appears to be abolished in type 2 diabetes and during NO synthase inhibition.
Databáze: OpenAIRE
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