Complex regional pain syndrome, prototype of a novel kind of autoimmune disease
| Autor: | Andreas Goebel, Franz Blaes |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Autoimmune disease
medicine.medical_specialty business.industry Immunology Immunoglobulins Intravenous medicine.disease Bioinformatics medicine.disease_cause Autoimmune Diseases Autoimmunity Complex regional pain syndrome Autoimmune Process Treatment modality Neuropathic pain medicine Physical therapy Animals Humans Immunologic Factors Immunology and Allergy Chronic Pain business Complex Regional Pain Syndromes Autonomic abnormalities Autonomic receptors |
| Zdroj: | Autoimmunity Reviews. 12:682-686 |
| ISSN: | 1568-9972 |
| DOI: | 10.1016/j.autrev.2012.10.015 |
| Popis: | Complex regional pain syndrome (CRPS) is a painful condition, which arises in a limb after trauma. CRPS can profoundly affect patients' quality of life, and there is no cure. CRPS is associated with limb-confined sensory, motor, skin, bone and autonomic abnormalities. Recent research has shown that some patients respond to treatment with immunoglobulins, and that a majority have IgG serum-autoantibodies directed against, and activating autonomic receptors. CRPS serum-IgG, when transferred to mice elicits abnormal behaviour. These results suggest that CRPS is associated with an autoantibody-mediated autoimmune process in some cases. CRPS has unusual features, including a non-destructive, and regionally-confined course. We propose that CRPS constitutes a prototype of a new kind of autoimmunity, which we term 'IRAM' (injury-triggered, regionally-restricted autoantibody-mediated autoimmune disorder with minimally-destructive course). Understanding autoimmune contribution to CRPS should allow the exploration of novel treatment modalities in the future. Additional 'functional' disorders, painful or painless may be autoimmune in nature. |
| Databáze: | OpenAIRE |
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