Insulin-like growth factor-I in Helicobacter pylori gastritis and response to eradication using bismuth based triple therapy
| Autor: | R. H. R. Park, G. Beastall, R. Morton, A. D. Beattie, Ali S. Taha |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Spirillaceae Enzyme-Linked Immunosorbent Assay Gastroenterology Helicobacter Infections Pathology and Forensic Medicine Insulin-like growth factor Metronidazole Internal medicine Gastric mucosa medicine Humans Insulin-Like Growth Factor I Chemotherapy Gastric Juice Helicobacter pylori biology business.industry Amoxicillin General Medicine Middle Aged biology.organism_classification Anti-Bacterial Agents medicine.anatomical_structure Gastric Mucosa Case-Control Studies Gastritis Immunology Drug Therapy Combination Female Antacids medicine.symptom business Bismuth Research Article medicine.drug |
| Zdroj: | Journal of Clinical Pathology. 49:676-678 |
| ISSN: | 0021-9746 |
| Popis: | AIMS: To measure insulin-like growth factor-I (IGF-I) concentrations in the presence and absence of Helicobacter pylori infection and in response to eradication of the organism. METHODS: An enzyme linked immunosorbent assay was used to measure gastric and fasting serum concentrations of IGF-I in 17 patients with and 11 without H pylori infection. Repeat assessments were performed in the infected patients six weeks after they received a two week course of bismuth chelate, metronidazole, and amoxycillin. RESULTS: IGF-I was detected at very low concentrations in gastric juice and in mucosal incubates. The median serum IGF-I concentration was 88 micrograms/l in the patients infected with H pylori compared with 90 micrograms/l in the non-infected controls; IGF-I concentrations dropped to 77 micrograms/l following eradication therapy (p = 0.014). CONCLUSION: The similarity in baseline IGF-I concentrations in the presence and absence of H pylori suggests that their subsequent drop after treatment is more likely to be due to the treatment. |
| Databáze: | OpenAIRE |
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