Dynamics of Synovial Fluid Aggregation under Shear
| Autor: | Delphine Gourdon, Mihir S. Samak, Evan Czako, Ya Guan, Noah J. Pacifici, Lawrence J. Bonassar, Sierra G Cook, Cory N. Brown |
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| Rok vydání: | 2019 |
| Předmět: |
Chemistry
Surface forces apparatus 02 engineering and technology Surfaces and Interfaces Tribology 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences 0104 chemical sciences chemistry.chemical_compound Rheology Shear (geology) Hyaluronic acid Electrochemistry Lubrication Biophysics Synovial fluid General Materials Science 0210 nano-technology Porous medium Spectroscopy |
| Zdroj: | Langmuir : the ACS journal of surfaces and colloids. 35(48) |
| ISSN: | 1520-5827 |
| Popis: | The synovial fluid (SF) that lubricates articular joints exhibits complex rheological and tribological properties due to the interactions and behaviors of its various molecular components. Under shear, SF films abruptly thicken by more than 300% and large, dense aggregates form within the fluid. In this study, we used the Surface Force Apparatus to elucidate which SF components are involved in this shear-induced transformation by (i) determining which (if any) of all major SF components replicate the behavior of SF under shear and (ii) observing the effect of removing implicated components from SF by enzymatic digestion. While most previous studies of SF have focused on the tribological roles of lubricin or hyaluronic acid, our results indicate that albumin is a key contributor to the formation of aggregates in SF under shear. Our results also suggest that SF aggregation is associated with efficient surface protection against wear. As our findings are based on experiments involving rigid, nonporous surfaces, they may be used to investigate shear-mediated aggregation mechanisms occurring during the lubrication of artificial joints, ultimately advancing our current vision of implant design. |
| Databáze: | OpenAIRE |
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