Aminopeptidase-N/CD13 (EC 3.4.11.2) inhibitors: Chemistry, biological evaluations, and therapeutic prospects

Autor: Brigitte Bauvois, Daniel Dauzonne
Přispěvatelé: Signalisation cellulaire, dynamique circulatoire et athérosclérose précoce (SCDCAP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)
Rok vydání: 2005
Předmět:
MESH: Hydroxamic Acids
natural inhibitor
Angiogenesis
medicine.medical_treatment
Pharmacology
Hydroxamic Acids
01 natural sciences
MESH: Tyrosine
0302 clinical medicine
MESH: Curcumin
Drug Discovery
MESH: Animals
Disulfides
Receptor
Neprilysin
0303 health sciences
aminopeptidase
MESH: Protease Inhibitors
MESH: Neprilysin
Chemistry
MESH: Antigens
CD13
General Medicine
Transmembrane protein
3. Good health
030220 oncology & carcinogenesis
MESH: Oligopeptides
Molecular Medicine
medicine.symptom
Pentacyclic Triterpenes
Oligopeptides
MESH: Neovascularization
Physiologic
hormones
hormone substitutes
and hormone antagonists
Cell type
bestatin
Curcumin
animal structures
Neovascularization
Physiologic
Inflammation
ectoenzyme
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
CD13 Antigens
Article
03 medical and health sciences
Immune system
Leucine
MESH: Cell Proliferation
synthetic inhibitor
medicine
cancer
Animals
Humans
Protease Inhibitors
MESH: Disulfides
Secretion
Betulinic Acid
Cell Proliferation
030304 developmental biology
MESH: Humans
Protease
010405 organic chemistry
Cell growth
MESH: Triterpenes
Triterpenes
0104 chemical sciences
MESH: Leucine
inflammation
Tyrosine
Zdroj: Med Res Rev
Med Res Rev, 2006, 26 (1), pp.88-130. ⟨10.1002/med.20044⟩
Medicinal Research Reviews
ISSN: 1098-1128
0198-6325
DOI: 10.1002/med.20044
Popis: Aminopeptidase N (APN)/CD13 (EC 3.4.11.2) is a transmembrane protease present in a wide variety of human tissues and cell types (endothelial, epithelial, fibroblast, leukocyte). APN/CD13 expression is dysregulated in inflammatory diseases and in cancers (solid and hematologic tumors). APN/CD13 serves as a receptor for coronaviruses. Natural and synthetic inhibitors of APN activity have been characterized. These inhibitors have revealed that APN is able to modulate bioactive peptide responses (pain management, vasopressin release) and to influence immune functions and major biological events (cell proliferation, secretion, invasion, angiogenesis). Therefore, inhibition of APN/CD13 may lead to the development of anti‐cancer and anti‐inflammatory drugs. This review provides an update on the biological and pharmacological profiles of known natural and synthetic APN inhibitors. Current status on their potential use as therapeutic agents is discussed with regard to toxicity and specificity. © 2005 Wiley Periodicals, Inc. Med Res Rev
Databáze: OpenAIRE
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