Early immunological monitoring after pediatric liver transplantation: cytokine immune deviation and graft acceptance in 40 recipients
| Autor: | Dominique Latinne, Dinh Quang Truong, Jean-Luc Vaerman, Etienne Sokal, Béatrice Délépaut, Jean-Bernard Otte, Jean de Ville de Goyet, Jeremie Gras, Anne Cornet, Grégoire Wieërs, Raymond Reding |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Adolescent medicine.medical_treatment Biopsy Context (language use) Liver transplantation Interferon-gamma Th2 Cells Monitoring Immunologic Predictive Value of Tests Medicine Humans Interferon gamma Prospective Studies Child Transplantation Hepatology medicine.diagnostic_test business.industry Tumor Necrosis Factor-alpha Graft Survival Infant Immunosuppression Th1 Cells Settore MED/20 - Chirurgia Pediatrica e Infantile Interleukin-10 Liver Transplantation surgical procedures operative Cytokine Liver Liver biopsy Child Preschool Immunology Cytokines Surgery Female business medicine.drug |
| Zdroj: | Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. 13(3) |
| ISSN: | 1527-6465 |
| Popis: | Cytokine deviation may be a factor contributing to graft acceptance. We analyze, in the context of liver transplantation, circulating cytokine levels and their mRNA precursors in liver biopsy samples to study a putative correlation with early immunologic outcome. Forty primary pediatric liver recipients were submitted to a prospective immune monitoring protocol, including 8 of 40 patients with an early, biopsy-proven acute rejection episode. The 32 patients with graft acceptance showed markedly increased interleukin (IL)-10 blood levels at 2 hours after reperfusion on days 1 and 4 after transplantation as compared with baseline, whereas patients with graft rejection only exhibited increased IL-10 levels at 2 hours. A good correlation was observed between IL-10 peripheral levels and levels ascertained by IL-10 reverse transcriptase-polymerase chain reaction at 2 hours and on day 7. Patients with graft acceptance also showed a decrease in interferon gamma (IFN-gamma) at 1 and 2 hours after reperfusion on days 1, 4, 7, 14, and 28 after transplantation. One patient with graft tolerance who had subsequent immunosuppression withdrawal after posttransplantation lymphoproliferative disease showed a similar intraoperative IL-10 pattern, whereas posttransplantation tumor necrosis factor alpha and IFN-gamma levels greatly decreased. The occurrence of cytokine immune deviation may therefore be related to early graft acceptance in children who receive liver transplants. |
| Databáze: | OpenAIRE |
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