Development and evaluation of a prototype detector for an intraoperative laparoscopic coincidence imaging system with PET tracers
| Autor: | Keiichi Nakagawa, Ichiro Sakuma, Kenji Shimazoe, M. R. Liyanaarachchi, Etsuko Kobayashi, Hiroyuki Takahashi |
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| Rok vydání: | 2020 |
| Předmět: |
Computer science
0206 medical engineering Biomedical Engineering Health Informatics 02 engineering and technology Iterative reconstruction 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Optics Silicon photomultiplier Data acquisition Stomach Neoplasms Gate array Image Processing Computer-Assisted medicine Humans Computer Simulation Radiology Nuclear Medicine and imaging Image resolution medicine.diagnostic_test business.industry Orientation (computer vision) Detector General Medicine 020601 biomedical engineering Computer Graphics and Computer-Aided Design Computer Science Applications Positron emission tomography Lymphatic Metastasis Positron-Emission Tomography Laparoscopy Surgery Computer Vision and Pattern Recognition business |
| Zdroj: | International Journal of Computer Assisted Radiology and Surgery. 16:29-39 |
| ISSN: | 1861-6429 1861-6410 |
| Popis: | Conventional positron emission tomography can be used only preoperatively to identify lymph node metastases, and hence, these growths are difficult to locate intraoperatively. Previously, an intraoperative laparoscopic coincidence imaging system, with an external fixed detector array and a detector probe that can be moved and inserted into the stomach, was proposed to identify lymph node metastases during stomach cancer surgery. This paper proposes a prototype detector for this system. GAGG:Ce (Gd3Al2Ga3O12:Ce) scintillator crystals, one to one coupled with silicon photomultipliers (SiPMs), were used to identify 511 keV photons. An optical tracking system followed the position and orientation of the movable detector. SiPM outputs were read out by time-over-threshold (TOT)-based application-specific integrated circuits, which converted the electrical charges into digital pulses. To identify the arrival time, channel number, and pulse width, which indicate the energy information of each TOT output, a data acquisition system was developed based on a field-programmable gate array. The spatial resolution of the reconstructed images in lateral direction was better than 7 mm, but that of depth direction was limited, owing to inadequate projections. The prototype successfully reconstructed 44 kBq 18F-fluorodeoxyglucose sources during a 2-min scan. We developed a prototype detector for an intraoperative laparoscopic coincidence imaging system. The prototype detector was evaluated successfully, and the produced images were similar to those obtained in the simulation results, thereby suggesting that this method offers a new possibility of imaging lymph node metastases intraoperatively. |
| Databáze: | OpenAIRE |
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