QRS Fragmentation and Sudden Cardiac Death in the Obese and Overweight
Autor: | Candice Kim, Lin Zhang, Kumar Narayanan, Audrey Uy-Evanado, Sumeet S. Chugh, Jonathan Jui, Kyndaron Reinier, Carmen Teodorescu, Karen Gunson, Zhi Jie Zheng |
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Jazyk: | angličtina |
Rok vydání: | 2015 |
Předmět: |
Male
obesity Time Factors 030204 cardiovascular system & hematology Overweight Ventricular Function Left Sudden cardiac death Electrocardiography Oregon 0302 clinical medicine Risk Factors Odds Ratio Prevalence Medicine Arrhythmia and Electrophysiology 030212 general & internal medicine Prospective Studies Prospective cohort study Original Research education.field_of_study Ejection fraction Middle Aged Prognosis Cardiology Female medicine.symptom Cardiology and Cardiovascular Medicine medicine.medical_specialty QRS fragmentation Population sudden cardiac death 03 medical and health sciences QRS complex Heart Conduction System Predictive Value of Tests Internal medicine Humans cardiovascular diseases education Aged Chi-Square Distribution business.industry ECG Case-control study Arrhythmias Cardiac Stroke Volume Odds ratio medicine.disease Death Sudden Cardiac Logistic Models Case-Control Studies Multivariate Analysis business |
Zdroj: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
ISSN: | 2047-9980 |
Popis: | Background Obesity has been associated with significantly greater risk of sudden cardiac death ( SCD ); however, identifying the obese patient at highest risk remains a challenge. We evaluated the association between QRS fragmentation on the 12‐lead electrocardiogram and SCD , in obese/overweight subjects. Methods and Results In the ongoing prospective, community‐based Oregon Sudden Unexpected Death Study (population approximately 1 million), we performed a case‐control analysis, comparing obese/overweight SCD victims with obese/overweight controls from the same geographic region. Archived ECG s prior and unrelated to the SCD event were used for cases and all ECG measurements were assessed in blinded fashion. Fragmentation was defined as the presence of RSR ’ patterns and/or notching of the R/S wave in at least 2 contiguous leads. Analysis was limited to ECG s with QRS duration P =0.06). Lateral fragmentation was significantly more frequent in cases (8.1% versus 2.5%; P P =0.02). In multivariable analysis with consideration of established SCD risk factors, lateral fragmentation was significantly associated with SCD ( OR 2.84; 95% CI 1.01 to 8.02; P =0.05). Conclusion QRS fragmentation, especially in the lateral territory is a potential risk marker for SCD independent of the ejection fraction, among obese/overweight subjects in the general population. |
Databáze: | OpenAIRE |
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