Cell-specific expression of aromatase and LH receptor mRNAs in rat ovary
| Autor: | C.M. Howles, P F Whitelaw, Stephen G. Hillier, C.D. Smyth |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
endocrine system
medicine.medical_specialty medicine.drug_class Gene Expression Ovary Paracrine signalling Endocrinology Aromatase Internal medicine Follicular phase Gene expression medicine Animals RNA Messenger Rats Wistar Molecular Biology In Situ Hybridization Hypophysectomy biology luteinizing hormone/choriogonadotropin receptor RNA Probes Receptors LH Rats medicine.anatomical_structure Cell culture biology.protein Female Gonadotropin Follicle Stimulating Hormone |
| Zdroj: | Journal of molecular endocrinology. 9(3) |
| ISSN: | 0952-5041 |
| Popis: | Current understanding of the endocrine and paracrine regulation of follicular oestrogen synthesis predicts that aromatase cytochrome P450 (P450arom) mRNA is inducible by FSH in granulosa cells. LH receptor mRNA is constitutively expressed in thecal/interstital cells, and is also thought to be induced in granulosa cells in response to joint stimulation by FSH and oestrogen. This study provides direct evidence that FSH induces the ovarian P450arom gene selectively, perhaps exclusively, in the granulosa cells of Graafian follicles. FSH-induction of LH receptor mRNA occurs simultaneously but is independent of oestrogen synthesis per se. |
| Databáze: | OpenAIRE |
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