Fecal Calprotectin Concentrations in Premature Infants Have a Lower Limit and Show Postnatal and Gestational Age Dependence
| Autor: | Stefan Wirth, Andreas Jenke, Luciano Zoppelli, Clemens Andrée, Christian Güttel, Hans-Jörg Bittrich |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Birth weight Gestational Age Context (language use) Sensitivity and Specificity Statistics Nonparametric Cohort Studies Feces Meconium Enterocolitis Necrotizing Predictive Value of Tests medicine Humans Infant Very Low Birth Weight Obstetrics business.industry Age Factors Infant Newborn Gestational age medicine.disease Low birth weight Postnatal age Pediatrics Perinatology and Child Health Necrotizing enterocolitis medicine.symptom Calprotectin business Leukocyte L1 Antigen Complex Infant Premature Developmental Biology |
| Zdroj: | Neonatology. 102:68-74 |
| ISSN: | 1661-7819 1661-7800 |
| Popis: | Background: There is a need for reliable diagnostic biomarkers in necrotizing enterocolitis (NEC). Whereas fecal calprotectin (fCP) has been reported to have insufficient sensitivity and specificity, no previous study has stratified for gestational and postnatal age. Objective: We aimed to provide developmental specific fCP data in premature infants and to analyze its value in detecting intestinal distress and episodes of NEC. Methods: Between April 2008 and December 2009, 1,899 fecal samples were obtained from 206 very low birth weight infants. Results: Mean gestational age (GA) was 28.5 weeks and birth weight 1,057 g. 19 (9.2%) patients developed NEC stage II+, of whom 5 had fulminant NEC with unusually low fCP concentrations in meconium and afterwards. fCP levels showed significant gestational and postnatal age dependent dynamics with particularly low levels in extremely premature infants. In infants with a GA Conclusions: fCP levels depend on gestational and postnatal age and in contrast to adults, there is a lower limit in premature infants. Taking these observations into account when defining reference values and interpreting fCP data in the clinical context, fCP can be a useful marker in identifying premature infants with gastrointestinal distress and NEC in particular. |
| Databáze: | OpenAIRE |
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