Effect of intravenous dopamine infusion on pituitary and thyroid function and on nephroprotection
| Autor: | Krzysztof Sciborski, Andrzej Mysiak, Małgorzata Kobusiak-Prokopowicz |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
Pituitary gland medicine.medical_specialty Dopamine Thyroid Gland Renal function Thyrotropin Adrenocorticotropic hormone Kidney Adrenocorticotropic Hormone Intensive care Internal medicine Internal Medicine medicine Humans Infusions Intravenous Aged Aged 80 and over Heart Failure business.industry Middle Aged medicine.disease Thyroxine medicine.anatomical_structure Endocrinology Heart failure Pituitary Gland Triiodothyronine Female Kidney Diseases Thyroid function business medicine.drug Hormone |
| Zdroj: | Scopus-Elsevier |
| Popis: | IntroductIon Catecholamines, including dopamine, are used in cardiac intensive care. objectIves The aim of the study was to assess the effect of intravenous dopamine infusion on the function of pituitary gland in patients with acute cardiac failure. We analyzed changes in the serum lev‑ els of thyroid-stimulating hormone (TSH) and adrenocorticotropic hormone (ACTH), as well as potential nephroprotection. PAtIents And methods The study involved 29 patients with chronic decompensated heart failure (New York Heart Association class III/IV; mean age 77.4 ±13.3 years). Dopamine was administered intrave‑ nously in doses varying from 1 to 5 μg/kg/min. Measurements of TSH, free triiodothyronine (FT 3 ), free thyroxine (FT 4 ), and ACTH were taken directly before dopamine infusion, after 12 hours of continuous infusion, and 12 hours after the 72-hour infusion was completed. results Serum FT 3 levels were significantly higher before dopamine infusion than at 12 hours post infusion (5.12 ±1.16 vs. 4.27 ±0.89 pmol/l, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|