LINE-1 retrotransposons: Modulators of quantity and quality of mammalian gene expression?
| Autor: | Jeffrey S. Han, Jef D. Boeke |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Cytoplasm
Retroelements Ultraviolet Rays Retrotransposon Biology Models Biological Genome General Biochemistry Genetics and Molecular Biology Epigenesis Genetic Evolution Molecular Open Reading Frames Gene expression Humans RNA Messenger Gene Alleles Recombination Genetic Regulation of gene expression Genetics Models Genetic DNA Exons Reverse transcriptase Long Interspersed Nucleotide Elements Gene Expression Regulation DNA Transposable Elements Human genome Function (biology) |
| Zdroj: | BioEssays. 27:775-784 |
| ISSN: | 1521-1878 0265-9247 |
| DOI: | 10.1002/bies.20257 |
| Popis: | LINE-1 (L1) retrotransposons are replicating repetitive elements that, by mass, are the most-abundant sequences in the human genome. Over one-third of mammalian genomes are the result, directly or indirectly, of L1 retrotransposition. L1 encodes two proteins: ORF1, an RNA-binding protein, and ORF2, an endonuclease/reverse transcriptase. Both proteins are required for L1 mobilization. Apart from the obvious function of self-replication, it is not clear what other roles, if any, L1 plays within its host. The sheer magnitude of L1 sequences in our genome has fueled speculation that over evolutionary time L1 insertions may structurally modify endogenous genes and regulate gene expression. Here we provide a review of L1 replication and its potential functional consequences. BioEssays 27:775–784, 2005. © 2005 Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
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