Dry Eye Disease: Present Challenges in the Management and Future Trends
| Autor: | Sai H.S. Boddu, Reginald F. Baugh, Rinda Devi Bachu, Allison Zimmerman, Surajit Dey, Zahoor A. Shah, Zahraa H F Al-Saedi |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty medicine.medical_treatment Keratoconjunctivitis Sicca Disease 03 medical and health sciences 0302 clinical medicine Risk Factors Drug Discovery medicine Humans KERATOCONJUNCTIVITIS SICCA Intensive care medicine Pharmacology business.industry Epithelium Corneal Treatment options Autologous serum eye diseases Review article Clinical trial Artificial tears 030104 developmental biology Tears 030221 ophthalmology & optometry Optometry sense organs Ophthalmic Solutions business Conjunctiva |
| Zdroj: | Current Pharmaceutical Design. 22:4470-4490 |
| ISSN: | 1381-6128 |
| Popis: | Dry eye disease (DED) is a tear film disorder resulting in hyperosmolarity of the tear film and inflammation of the ocular surface. DED is also referred to as keratoconjunctivitis sicca (KCS) and dry eye syndrome. DED represents a significant public health issue, particularly in older adults, and needs more research and attention. Despite the urgent need for safe and effective pharmacotherapies, there is currently only one approved medication, Restasis ® , to tackle DED. In this review article, we present an overview of DED, classification, epidemiology, pathophysiology, diagnosis, and risk factors of DED. Special emphasis is placed on current treatment options for DED such as artificial tears, lipid-containing lubricants, liposomal spray, inserts, anti-inflammatory or immunosuppressant drops, antibiotics, dietary omega-3 essential fatty acids, autologous serum, intense-pulsed-light (IPL), punctual plugs, moisture-retaining eyeglasses, hydrophilic bandage contact lenses and secretagogues. The review also summarizes trends in DED treatment that are patented and are currently under investigation in clinical trials. |
| Databáze: | OpenAIRE |
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