Anticholinergics aggravate the imbalance of the autonomic nervous system in stable chronic obstructive pulmonary disease

Autor: Nan Jia, Shan Nie, Qiufen Xu, Haoyan Wang, Wei Yuan
Rok vydání: 2019
Předmět:
Male
Pulmonary and Respiratory Medicine
Cardiac function curve
medicine.medical_specialty
Pulmonary disease
Autonomic Nervous System
Cholinergic Antagonists
Pulmonary Disease
Chronic Obstructive
03 medical and health sciences
0302 clinical medicine
Heart Rate
Internal medicine
Administration
Inhalation
Heart rate
Humans
Medicine
In patient
Prospective Studies
030212 general & internal medicine
Tiotropium Bromide
Autonomic nervous imbalance
Aged
Peak exercise
lcsh:RC705-779
COPD
business.industry
Chronic obstructive pulmonary disease
lcsh:Diseases of the respiratory system
Middle Aged
medicine.disease
Bronchodilator Agents
Respiratory Function Tests
respiratory tract diseases
Autonomic nervous system
Heart rate recovery
Increased risk
030228 respiratory system
Cardiovascular Diseases
Multivariate Analysis
Exercise Test
Cardiology
Regression Analysis
Female
business
human activities
Anticholinergics
Research Article
Zdroj: BMC Pulmonary Medicine
BMC Pulmonary Medicine, Vol 19, Iss 1, Pp 1-6 (2019)
ISSN: 1471-2466
DOI: 10.1186/s12890-019-0848-0
Popis: Background Inhaled anticholinergics, recommended as first-line maintenance treatment for patients with moderate-to-severe chronic obstructive pulmonary disease (COPD), has been demonstrated to be associated with an increased risk of cardiovascular diseases. Nevertheless, why COPD patients using inhaled anticholinergics have this higher risk remains unknown. One of mechanisms may be an autonomic imbalance because anticholinergics yield reduced vagal nervous activity. To test our hypothesis, we studied heart rate recovery (HRR) after exercise, recognized as a marker of cardiac autonomic function, in COPD patients using and not using inhaled anticholinergics. Methods Sixty patients with COPD were involved in this study (mean FEV1 = 1.57 ± 0.42 L), including 24 patients who had received tiotropium for more than 1 year and 36 patients not using tiotropium as a control group. A maximal cardiopulmonary exercise test was performed. HRR was defined as the difference between peak exercise and at 1-min recovery heart rate. Results HRR was significantly lower in patients using tiotropium than in the controls (16 ± 6 vs 22 ± 8 beats/min, respectively, p
Databáze: OpenAIRE
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