The Effective Mutation Rate at Y Chromosome Short Tandem Repeats, with Application to Human Population-Divergence Time
| Autor: | Zhivotovsky, L. A., Underhill, P. A., Cinnioglu, C., Kayser, M., Morar, B., Kivisild, T., Scozzari, Rosaria, Cruciani, Fulvio, DESTRO-BISOL, Giovanni, Giovanni Destro Bisol, Spedini, G., Chambers, G. K., Herrera, R. J., Yong, K. K., Gresham, D., Tournev, I., Feldman, M. W., Kalaydjieva, L. |
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| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Male
Mutation rate Human Y-chromosome DNA haplogroup Population Locus (genetics) Biology Y chromosome Haplogroup Polynesia White People 03 medical and health sciences Genetics Humans Genetics(clinical) microsateliltes education Y-SNP Genetics (clinical) 030304 developmental biology 0303 health sciences education.field_of_study Chromosomes Human Y Models Genetic 030305 genetics & heredity Chromosome Mapping Genetic Variation Articles Tandem Repeat Sequences Mutation y chromosome Microsatellite Female New Zealand |
| Popis: | We estimate an effective mutation rate at an average Y chromosome short-tandem repeat locus as 6.9×10 −4 per 25 years, with a standard deviation across loci of 5.7×10 −4 , using data on microsatellite variation within Y chromosome haplogroups defined by unique-event polymorphisms in populations with documented short-term histories, as well as comparative data on worldwide populations at both the Y chromosome and various autosomal loci. This value is used to estimate the times of the African Bantu expansion, the divergence of Polynesian populations (the Maoris, Cook Islanders, and Samoans), and the origin of Gypsy populations from Bulgaria. |
| Databáze: | OpenAIRE |
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