5-Aminolevulinic acid: A matter of life and caveats
| Autor: | Luiz D. Ramos, Etelvino J. H. Bechara, Cassius V. Stevani |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Protoporphyrin IX
medicine.medical_treatment Photodynamic therapy Mitochondrion Pharmacology 010402 general chemistry 01 natural sciences chemistry.chemical_compound Electrochemistry medicine Heme QD1-999 Acute intermittent porphyria Photodamage ESTRESSE OXIDATIVO biology Porphyria 010405 organic chemistry medicine.disease 0104 chemical sciences Chemistry chemistry Catalase 5-aminolevulinic acid Oxidative stress biology.protein Erythropoietic protoporphyria Hemoglobin |
| Zdroj: | Journal of Photochemistry and Photobiology, Vol 7, Iss, Pp 100036-(2021) Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 2666-4690 |
| Popis: | Our mini-review concerns the potential adverse pro-oxidant role of 5-aminolevulinic (ALA), the first protoporphyrin IX (PP-IX)/heme precursor widely used in commercial formulations for endogenous photodynamic therapy (PDT). Our account collates the two sides of (i) ALA aerobic oxidation as a source of H2O2 and radicals when accumulated in acute intermittent porphyria (AIP), hereditary tyrosinemia type 1 (HT1), and lead poisoning, thereby triggering similar biochemical damage and symptoms and (ii) the central role of PP-IX as the immediate precursor of the heme prosthetic group of key proteins and enzymes (hemoglobin, myoglobin, cytochromes, catalase, and others). Conversely, PP-IX induces skin photodamage when accumulated in sun-exposed erythropoietic protoporphyria (EPP) patients. Furthermore, we highlight the harnessing of such antithetical ALA and PP-IX properties to design efficient PDT and insecticidal strategies. Research on ALA-based PDT photosensitizers calls for more attention on the deleterious action of excess ALA, whose main target is the mitochondrion. |
| Databáze: | OpenAIRE |
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