Effects of inhalation exposure to hexachlorocyclopentadiene on rats and monkeys
| Autor: | P. O. Nees, G. C. Clark, C. J. Calo, G. M. Rand, D. J. Alexander |
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| Rok vydání: | 1982 |
| Předmět: |
Male
Pathology medicine.medical_specialty Physiology Toxicology Lethal Dose 50 chemistry.chemical_compound Sex Factors medicine Hydrocarbons Chlorinated Animals Respiratory system Bronchiolar epithelium Lung Inhalation exposure Inhalation business.industry Body Weight Rats Inbred Strains Hexachlorocyclopentadiene Pollution Rats Macaca fascicularis medicine.anatomical_structure chemistry Toxicity Female business Inflammatory exudate Respiratory tract |
| Zdroj: | Journal of toxicology and environmental health. 9(5-6) |
| ISSN: | 0098-4108 |
| Popis: | Hexachlorocyclopentadiene (Hex or C-56) is a highly reactive intermediate used in the production of some insecticides, flame retardants, and resins. The present study was conducted to evaluate the inhalation toxicity of high-purity Hex (97.7%) in rats and monkeys to provide information on the potential hazards of accidental exposure of workers to Hex vapors. Acute, range-finding (14-d), and subchronic (90-d) inhalation studies were conducted with Sprague-Dawley rats and subchronic (90-d) inhalation studies were conducted with cynomolgus monkeys. Both acute and range-finding studies with rats showed a steep dose-response curve, and male rats were more sensitive than females. In the range-finding study with rats the threshold of toxicity for Hex was 0.11-0.5 ppm. Histopathologic examination on rats in the 0.5 ppm group revealed lesions in the olfactory and bronchiolar epithelium and inflammatory exudate in the lumens of the respiratory tract; these changes were consistent with observed impaired respiratory function, confirming the lung as the main target organ. Recovery and regression of lung lesions in rats were noted 2-3 wk after termination of exposure. In the 90-d study, inhalation of Hex vapors at concentrations up to 0.2 ppm for 6 h/d, 5 d/wk, produced no detectable physical or clinical effect and no remarkable gross or histological alterations in rats or monkeys. |
| Databáze: | OpenAIRE |
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