CD8 and CD4 T cell-mediated polymyositis complicating the HTLV-1 associated myelopathy. Quantitative evaluation of corticosteroid treatment
| Autor: | Andrew J. Waclawik, Paul J. Lewandoski, Brad R. Beinlich, Ricardo Fadic, Barend P. Lotz, Benjamin Rix Brooks, Mohammed Sanjak |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
Pathology medicine.medical_specialty Weakness Biopsy CD8 Antigens Anti-Inflammatory Agents Fluorescent Antibody Technique Polymyositis Inflammatory myopathy Myelopathy Atrophy medicine Humans Muscle Skeletal Creatine Kinase Denervation Muscle biopsy medicine.diagnostic_test business.industry General Medicine Middle Aged medicine.disease HTLV-I Infections Paraparesis Tropical Spastic Neurology CD4 Antigens Prednisone Neurology (clinical) medicine.symptom business |
| Zdroj: | Acta Neurologica Scandinavica. 94:115-119 |
| ISSN: | 1600-0404 0001-6314 |
| DOI: | 10.1111/j.1600-0404.1996.tb07040.x |
| Popis: | Introduction - Inflammatory myopathy is a treatable cause of worsening in the spectrum of neurological conditions that may develop during the course of HTLV-1 infection. Material and methods - To investigate the cause of subacute worsening in the strength of a 46-y-old black male with HTLV-1 associated myelopathy we performed electrodiagnostic examination and a muscle biopsy which was studied with histochemistry, immunocytochemistry and electron microscopy. Serial measurements of isometric muscle strength were performed during the course of corticosteroid treatment. Results - The muscle biopsy showed evidence of denervation atrophy and prominent inflammatory changes with autoaggressive features. Lymphocyte typing showed a predominance of CD8 + T cells. The patient had sustained, marked improvement in strength, especially of the upper extremities, with oral, high single-dose, alternate-day prednisone therapy. Conclusion - A muscle biopsy should be considered in all patients with HTLV-1 associated weakness, especially when electromyography indicates possible coexisting primary muscle involvement and/or serum creatine kinase levels are elevated. HTLV-1-associated polymyositis can be successfully treated with corticosteroids. |
| Databáze: | OpenAIRE |
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