Use of Multifactorial Treatments to Address the Challenge of Translating Experimental Myocardial Infarct Reduction Strategies

Autor: Jitka A. I. Virag, Julie L. Horton
Rok vydání: 2019
Předmět:
0301 basic medicine
medicine.medical_specialty
ephrinA1
Cardiotonic Agents
Recombinant Fusion Proteins
medicine.medical_treatment
Myocardial Infarction
Ischemia
Review
ischemia
Disease
030204 cardiovascular system & hematology
Ligands
Catalysis
lcsh:Chemistry
Translational Research
Biomedical
Inorganic Chemistry
03 medical and health sciences
0302 clinical medicine
medicine
Animals
Humans
Myocardial infarction
Physical and Theoretical Chemistry
Intensive care medicine
lcsh:QH301-705.5
therapeutic strategies
Molecular Biology
Spectroscopy
Reduction (orthopedic surgery)
Cardioprotection
Myocardial tissue
business.industry
Organic Chemistry
Disease Management
Ephrin-A1
General Medicine
medicine.disease
Combined Modality Therapy
reperfusion
Immunoglobulin Fc Fragments
Computer Science Applications
Functional integrity
Treatment Outcome
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
cardioprotection
business
Zdroj: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 20, Iss 6, p 1449 (2019)
ISSN: 1422-0067
Popis: Myocardial tissue damage that occurs during an ischemic event leads to a spiraling deterioration of cardiac muscle structural and functional integrity. Reperfusion is the only known efficacious strategy and is the most commonly used treatment to reduce injury and prevent remodeling. However, timing is critical, and the procedure is not always feasible for a variety of reasons. The complex molecular basis for cardioprotection has been studied for decades but formulation of a viable therapeutic that can significantly attenuate myocardial injury remains elusive. In this review, we address barriers to the development of a fruitful approach that will substantially improve the prognosis of those suffering from this widespread and largely unmitigated disease. Furthermore, we proffer that ephrinA1, a candidate molecule that satisfies many of the important criteria discussed, possesses robust potential to overcome these hurdles and thus offers protection that surpasses the limitations currently observed.
Databáze: OpenAIRE
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