Homogeneous Immunoglobulins following Allogeneic Bone Marrow Transplantation
| Autor: | Katalin Pálóczi, Andrea Sipos, Ferenc Uher, Melinda Hajdu, Puskás E, Anikó Barta |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Immunofixation Pathology medicine.medical_specialty Adolescent T cell Immunoglobulins Biology Leukemia Myelogenous Chronic BCR-ABL Positive hemic and lymphatic diseases Immunopathology medicine Humans Transplantation Homologous Immunodeficiency B cell Bone Marrow Transplantation B-Lymphocytes Models Immunological Antibodies Monoclonal Myeloid leukemia Hematology General Medicine Middle Aged medicine.disease Transplantation Transplantation Isogeneic medicine.anatomical_structure Immunology biology.protein Female Antibody Antibody Diversity |
| Zdroj: | Acta Haematologica. 109:124-128 |
| ISSN: | 1421-9662 0001-5792 |
| DOI: | 10.1159/000069285 |
| Popis: | Homogeneous immunoglobulins are frequently detected in the serum of patients undergoing allogeneic bone marrow transplantation (BMT). The aim of the present study was to further characterize the incidence of this phenomenon and its correlations with laboratory and clinical data. Serum samples were gathered from 29 patients undergoing allogeneic or syngeneic BMT for chronic myeloid leukemia (CML), and serial protein (IgG, IgA and IgM) quantification, electrophoresis and immunofixation were performed. Transient mono- or oligoclonal gammopathies were observed in 23 out of 29 patients between days 20 and 1,750 following transplantation. The presence of homogeneous immunoglobulins was not correlated with the following clinical parameters: graft-versus-host disease, bacterial sepsis, Epstein-Barr virus or cytomegalovirus infection or invasive fungal infection. Therefore, the development of mono- or oligoclonal immunoglobulins may represent a complex disorder of B cell regeneration which may be caused by an intrinsic B cell defect, or a failure in the regenerating T cell system, or both, manifesting itself in a restricted antibody diversity after allogeneic BMT. |
| Databáze: | OpenAIRE |
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