Prevalent Herpes Simplex Virus-2 Increases the Risk of Incident Bacterial Vaginosis in Women from South Africa

Autor: Sarita Naidoo, Gita Ramjee, Makandwe Nyirenda, Nathlee Abbai
Rok vydání: 2017
Předmět:
Adult
medicine.medical_specialty
Social Psychology
Herpesvirus 2
Human
030231 tropical medicine
Psychological intervention
Administration
Oral
HIV Infections
medicine.disease_cause
Article
law.invention
South Africa
Young Adult
03 medical and health sciences
0302 clinical medicine
Double-Blind Method
Randomized controlled trial
Risk Factors
law
HIV Seronegativity
Internal medicine
medicine
Humans
030212 general & internal medicine
Risk factor
Tenofovir
Developing Countries
Herpes Genitalis
Unsafe Sex
business.industry
Emtricitabine
Tenofovir Disoproxil Fumarate Drug Combination
Incidence
Public health
Incidence (epidemiology)
Hazard ratio
Public Health
Environmental and Occupational Health
Vaginosis
Bacterial
medicine.disease
Administration
Intravaginal
Cross-Sectional Studies
Infectious Diseases
Herpes simplex virus
Immunology
Female
Bacterial vaginosis
business
Gels
Zdroj: AIDS and Behavior. 22:2172-2180
ISSN: 1573-3254
1090-7165
Popis: Studies have shown that women diagnosed with herpes simplex virus-2 (HSV-2) have a higher risk for bacterial vaginosis (BV) infection. We investigated the presence of HSV-2 infections as a risk factor for incident BV infections in high risk, Human immunodeficiency virus (HIV) uninfected women enrolled in a HIV prevention trial in Durban, South Africa. The Vaginal and Oral Interventions to Control the Epidemic trial was a multicentre, double blinded, randomized controlled trial which was designed to estimate the effectiveness of daily treatment with vaginal tenofovir gel, oral tenofovir disoproxil fumarate and oral Truvada in preventing HIV-1 infection in women. Women provided samples for the diagnosis of HSV-2 and BV. The presence of HSV-2 antibodies was detected using HerpeSelect™ ELISA IgG. Bacterial vaginosis was diagnosed using the Nugent scoring system. To assess the risk of BV incidence, modelled as a time-dependent variable, we used the Andersen-Gill model with robust variance estimation and Efron methods for ties. Overall, 2750 women were enrolled in the VOICE trial at our study sites. Women who had a HSV-2 infection at enrolment were shown to be at increased risk for incident BV infections (adjusted hazard ratio 1.17, 95% CI 1.08, 1.27, p ≤ 0.001). In addition, being of a young age, being unmarried and having a partner that has other partners were significantly associated with subsequent BV infection. Our findings therefore advocate the need for strengthening STI prevention efforts among women in high burden STI settings.
Databáze: OpenAIRE
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