Visual field progression in Malay patients with primary glaucoma: survival analysis and prognostic factors
Autor: | Bachok Norsa'adah, Abdul Satar Huwaina, Wan Masri Wan-Ezatul-Arisha, Shi Jin Diana-Toh, Yaakub Azhany, Ahmad Tajudin Liza-Sharmini, Majdi Yaakob Najib |
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Rok vydání: | 2021 |
Předmět: |
medicine.medical_specialty
Intraocular pressure genetic structures Glaucoma Cellular and Molecular Neuroscience Internal medicine medicine Eye Pain Humans Intraocular Pressure Survival analysis Retrospective Studies Malay business.industry Malaysia Retrospective cohort study Prognosis medicine.disease Survival Analysis eye diseases Sensory Systems language.human_language Confidence interval Visual field Ophthalmology Disease Progression language Primary glaucoma Visual Field Tests Visual Fields Glaucoma Angle-Closure business Glaucoma Open-Angle |
Zdroj: | Graefe's Archive for Clinical and Experimental Ophthalmology. 260:2003-2012 |
ISSN: | 1435-702X 0721-832X |
DOI: | 10.1007/s00417-021-05466-9 |
Popis: | This study aims to determine the 5-year visual field progression and identify the prognostic factors for progression in Malay patients with primary glaucoma. A retrospective cohort record review study was conducted among 222 patients (222 eyes) with primary glaucoma who were selected from a glaucoma research database of a tertiary center in Malaysia. The patients were Malays and diagnosed with primary open-angle glaucoma (POAG) or primary angle-closure glaucoma (PACG). Patients who were followed up regularly for at least 6 months between 1 January 2009 and 31 December 2014 and completed another 1-year follow-up after recruitment (between 1 January 2015 and 31 December 2015) were selected. Multiple prognostic factors that influence visual field progression were identified. Progression of visual field loss was based on the Advanced Glaucoma Intervention Study and Hodapp–Parrish–Anderson scores. Kaplan–Meier survival and Cox proportional hazard regression analyses were performed. Sixty-three patients (28.4%) developed visual field progression after a mean (SD) follow-up of 6.9 (3.3) years. Those with POAG progressed faster (mean time, 10.6 years; 95% confidence interval [CI], 9.3, 11.9) than those with PACG (17.3 years; 95% CI, 14.8, 19.9) but not statistically significant. Disc hemorrhage and history of eye pain increased the risk of progression by 2.8-folds (95% CI, 1.6, 4.8) and 2.5-folds (1.4, 4.4), respectively. The 5-year survival of the Malay primary glaucoma patients with visual field progression was similar with that of other Asian populations. However, aggressive management is required for those with disc hemorrhages and eye pain related to increased intraocular pressure. |
Databáze: | OpenAIRE |
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