Dissecting the gray zone between follicular lymphoma and marginal zone lymphoma using morphological and genetic features
| Autor: | F. Bot, L. Braaf, Max Beijert, P. Gonzalez, Bauke Ylstra, S. Slot, O.B. Ponz, K. van Groningen, Margaretha G.M. Roemer, Annegien Broeks, Ron M. Kerkhoven, Oscar Krijgsman, D. de Jong |
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| Přispěvatelé: | Pathology, CCA - Disease profiling |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male EXPRESSION Pathology medicine.medical_specialty endocrine system Marginal zone lymphoma Follicular lymphoma Chromosomal translocation Biology ABERRATIONS World health T(14/18) BCL2 GENE immune system diseases hemic and lymphatic diseases medicine Humans COMPARATIVE GENOMIC HYBRIDIZATION Lymphoma Follicular Aged Aged 80 and over ABNORMALITIES MUTATIONS Hematology Lymphoma B-Cell Marginal Zone Articles Middle Aged medicine.disease TRANSFORMATION Lymphoma TRANSLOCATION COPY NUMBER Chromosome 3 Female Early phase Comparative genomic hybridization |
| Zdroj: | Haematologica, 98(12), 1921-1929. Ferrata Storti Foundation Krijgsman, O, Gonzalez, P, Ponz, O B, Roemer, M G M, Slot, S, Broeks, A, Braaf, L, Kerkhoven, R M, Bot, F, van Groningen, K, Beijert, M, Ylstra, B & de Jong, D 2013, ' Dissecting the gray zone between follicular lymphoma and marginal zone lymphoma using morphological and genetic features ', Haematologica, vol. 98, no. 12, pp. 1921-1929 . https://doi.org/10.3324/haematol.2013.085118 Haematologica, 98(12), 1921-1929. FERRATA STORTI FOUNDATION |
| ISSN: | 0390-6078 |
| DOI: | 10.3324/haematol.2013.085118 |
| Popis: | Nodal marginal zone lymphoma is a poorly defined entity in the World Health Organization classification, based largely on criteria of exclusion and the diagnosis often remains subjective. Follicular lymphoma lacking t(14;18) has similar characteristics which results in a major potential diagnostic overlap which this study aims to dissect. Four subgroups of lymphoma samples (n=56) were analyzed with high-resolution array comparative genome hybridization: nodal marginal zone lymphoma, t(14;18)-negative follicular lymphoma, localized t(14:18)-positive follicular lymphoma and disseminated t(14;18)-positive follicular lymphoma. Gains on chromosomes 7, 8 and 12 were observed in all subgroups. The mean number of aberrations was higher in disseminated t(14;18)-positive follicular lymphoma than in localized t(14:18)-positive follicular lymphoma ( P |
| Databáze: | OpenAIRE |
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