Kinetic Evaluation of the Ciliotoxicity of Methyl- and Propyl-p-hydroxybenzoates Using Factorial Experiments
| Autor: | A. Li Wan Po, L. Jian |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
Pharmacology Aqueous solution Chromatography Chemistry Stereochemistry Parabens Pharmaceutical Science Drug Synergism Factorial experiment In Vitro Techniques Rats Paraben Trachea Kinetics chemistry.chemical_compound Propyl hydroxybenzoate Hydroxybenzoate Prohibitins Toxicity Animals Cilia Rats Wistar Selectivity Hydroxybenzoates |
| Zdroj: | Journal of Pharmacy and Pharmacology. 45:98-101 |
| ISSN: | 2042-7158 0022-3573 |
| DOI: | 10.1111/j.2042-7158.1993.tb03691.x |
| Popis: | The ciliotoxicity of methyl-p-hydroxybenzoate (methyl paraben, MHB) and propyl hydroxybenzoate (propyl paraben, PHB) was investigated. It is shown that at the concentrations used (0·28 and 0·38 Mm) PHB exerted only mild toxicity. The MHB solutions used (1·18 and 2·36 Mm) were much more ciliotoxic. There was, however, an order of magnitude difference in the concentrations used as a result of constraints imposed by their differing aqueous solubilities. There was no evidence of synergism in the ciliotoxicity of the two compounds when the MHB concentration was raised from 1·18 to 2·36 Mm and the PHB concentration was raised from 0·28 to 0·38 Mm in a 22 factorial experiment. At those levels the two compounds showed additive effects. On the other hand, clear synergism was evidenced by the fact that the ciliotoxicity of both MHB and PHB was dependent on whether the cilia were exposed to each hydroxybenzoate singly or in combination. The results combined with those of an earlier study, indicate that it is not possible to improve the selectivity of antimicrobial activity without also increasing ciliotoxicity. |
| Databáze: | OpenAIRE |
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