CARDIOVASCULAR EFFECTS OF ETOMIDATE WITH EMPHASIS ON REGIONAL MYOCARDIAL BLOOD FLOW AND PERFORMANCE
| Autor: | K. M. Dhasmana, O. Prakash, Pieter D. Verdouw, Pramod R. Saxena |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Cardiac output
medicine.medical_specialty Swine Hemodynamics Coronary circulation Coronary Circulation Internal medicine Animals Medicine Etomidate Cardiac Output Renal circulation Dose-Response Relationship Drug business.industry Myocardium Imidazoles Blood flow Myocardial Contraction Anesthesiology and Pain Medicine medicine.anatomical_structure Blood pressure Cerebral blood flow Regional Blood Flow Anesthesia Renal blood flow Cardiology business |
| Zdroj: | British Journal of Anaesthesia. 53:591-599 |
| ISSN: | 0007-0912 |
| DOI: | 10.1093/bja/53.6.591 |
| Popis: | The effects of 30-min infusions of etomidate 0.03, 0.06, 0.12 and 0.24 mg kg−1 min−1 on systemic and regional haemodynamic variables and cardiac performance and metabolism were studied in pigs. The drug caused moderate, but dose-dependent, decreases in the cardiac output, arterial pressure and LV dP/dt max. Myocardial wall thickening, measured by echographic analysis, was decreased by the drug. However, heart rate, myocardial blood flow distribution and myocardial metabolism of lactate, glucose and free fatty acids remained unchanged. Cerebral blood flow was decreased substantially. However, renal blood flow changed only slightly. |
| Databáze: | OpenAIRE |
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