Silicosis and autoimmunity
| Autor: | Hiroaki Hayashi, Suni Lee, Takemi Otsuki, Hidenori Mastuzaki, Naoko Kumagai-Takei |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Inflammasomes T-Lymphocytes Immunology Silicosis Autoimmunity medicine.disease_cause Asbestos 03 medical and health sciences Asbestos fibers medicine Immunology and Allergy Animals Humans Autoantibodies business.industry Environmental exposure Environmental Exposure medicine.disease Silicon Dioxide 030104 developmental biology business |
| Zdroj: | Current opinion in allergy and clinical immunology. 17(2) |
| ISSN: | 1473-6322 |
| Popis: | Of the various environmental, occupational, and medical substances that cause dysregulation of autoimmunity, the effects and causative mechanisms of silica particles and asbestos fibers are discussed in this review.With respect to silica, many epidemiological studies have shown a significant association between silica exposure and the occurrence of autoimmune diseases. Although the importance of the NACHT, LRR and PYD domains-containing protein 3 (NALP3) inflammasome as the initial immune reaction against silica particles has been identified, the mechanisms involved that lead to various autoimmune diseases in patients exposed to silica remain largely unknown. Silica can activate various immune cells and investigation of the associated imbalance of regulatory T cells, responder T cells as well as Th17 cells might be key in furthering our understanding of silica-induced autoimmune alterations. On the other hand, asbestos exposure shows less association with autoimmune diseases. However, interesting findings pertaining to the detection of antiendothelial and mesothelial cell antibodies in asbestos-exposed patients have been reported.Taken together, further investigations may contribute in delineating the mechanisms involved in environmental factor-induced modification of autoimmunity. |
| Databáze: | OpenAIRE |
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