Lesions of the paraventricular thalamic nucleus attenuates prepulse inhibition of the acoustic startle reflex
| Autor: | Ayşe Özçetin, Pınar Öz, Tayfun Gözler, I. Tayfun Uzbay, F. Duygu Kaya Yertutanol |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Reflex Startle Midline Thalamic Nuclei Hippocampus Motor Activity Nucleus accumbens Amygdala Lesion 03 medical and health sciences 0302 clinical medicine medicine Animals Rats Wistar Prefrontal cortex Prepulse inhibition Prepulse Inhibition Chemistry General Neuroscience Sensory Gating Rats 030104 developmental biology medicine.anatomical_structure Acoustic Stimulation Acoustic Startle Reflex medicine.symptom Nucleus Neuroscience psychological phenomena and processes 030217 neurology & neurosurgery |
| Zdroj: | Neuroscience Letters. 642:31-36 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/j.neulet.2017.01.056 |
| Popis: | The paraventricular thalamic nucleus (PVT) is a midline nucleus with strong connections to cortical and subcortical brain regions such as the prefrontal cortex, amygdala, nucleus accumbens and hippocampus and receives strong projections from brain stem nuclei. Prepulse inhibition (PPI) is mediated and modulated by complex cortical and subcortical networks that are yet to be fully identified in detail. Here, we suggest that the PVT may be an important brain region for the modulation of PPI. In our study, the paraventricular thalamic nuclei of rats were electrolytically lesioned. Two weeks after the surgery, the PPI responses of the animals were monitored and recorded using measurements of acoustic startle reflex. Our results show that disruption of the PVT dramatically attenuated PPI at prepulse intensities of 74, 78 and 86dB compared to that in the sham lesion group. Thus, we suggest that the PVT may be an important part of the PPI network in the rat brain. |
| Databáze: | OpenAIRE |
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