Mechanisms for lyssavirus persistence in non-synanthropic bats in Europe: insights from a modeling study

Autor: Raphaëlle Métras, Vittoria Colizza, Andrea Apolloni, Jordi Serra-Cobo, Marc López-Roig, Hervé Bourhy, Chiara Poletto, Davide Colombi
Přispěvatelé: ISI Foundation Institute for Scientific Interchange, University of Turin, Universitat de Barcelona (UB), Animal, Santé, Territoires, Risques et Ecosystèmes (UMR ASTRE), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA), Université de Montpellier (UM), Institut Sénégalais de Recherches Agricoles [Dakar] (ISRA), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Centre National de Référence de la Rage-Dynamique des Lyssavirus et adaptation à l'hôte (CNR), Institut Pasteur [Paris], Universitat de Barcelona, European Project: 278433,EC:FP7:HEALTH,FP7-HEALTH-2011-two-stage,PREDEMICS(2011), Università degli studi di Torino = University of Turin (UNITO), Institut Pasteur [Paris] (IP)
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Virologia
lcsh:Medicine
Myotis myotis
Adaptive Immunity
L73 - Maladies des animaux
Persistence (computer science)
Sexual Behavior
Animal
0302 clinical medicine
Theoretical
Models
Chiroptera
Zoonoses
Bats
Artificial induction of immunity
lcsh:Science
Multidisciplinary
biology
Caves
Habitat
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
Veterinary medicine and animal Health
Public Health
Seasons
Autre (Sciences du Vivant)
Sexual Behavior
Zoology
Metapopulation
Article
Ratapinyades
03 medical and health sciences
Animal Migration
Animals
Ecosystem
Humans
Lyssavirus
Models
Theoretical
Rhabdoviridae Infections
Spain
Virology
medicine
[SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health
Animal
Host (biology)
lcsh:R
medicine.disease
biology.organism_classification
030104 developmental biology
Médecine vétérinaire et santé animal
Rabies
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
lcsh:Q
030217 neurology & neurosurgery
Zdroj: Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports 1 (9), 1-11. (2019)
Dipòsit Digital de la UB
Universidad de Barcelona
Scientific Reports
Scientific Reports, Nature Publishing Group, 2019, 9, pp.537. ⟨10.1038/s41598-018-36485-y⟩
Recercat. Dipósit de la Recerca de Catalunya
instname
Scientific Reports, Nature Publishing Group, 2019, 9 (1), pp.537. ⟨10.1038/s41598-018-36485-y⟩
Scientific Reports, 2019, 9 (1), pp.537. ⟨10.1038/s41598-018-36485-y⟩
ISSN: 2045-2322
Popis: Bats are natural reservoirs of the largest proportion of viral zoonoses among mammals, thus understanding the conditions for pathogen persistence in bats is essential to reduce human risk. Focusing on the European Bat Lyssavirus subtype 1 (EBLV-1), causing rabies disease, we develop a data-driven spatially explicit metapopulation model to investigate EBLV-1 persistence in Myotis myotis and Miniopterus schreibersii bat species in Catalonia. We find that persistence relies on host spatial structure through the migratory nature of M. schreibersii, on cross-species mixing with M. myotis, and on survival of infected animals followed by temporary immunity. The virus would not persist in the single colony of M. myotis. Our study provides for the first time epidemiological estimates for EBLV-1 progression in M. schreibersii. Our approach can be readily adapted to other zoonoses of public health concern where long-range migration and habitat sharing may play an important role.
Databáze: OpenAIRE
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