Clinical characteristics of patients in a case control study of sarcoidosis
| Autor: | ROBERT P. BAUGHMAN, ALVIN S. TEIRSTEIN, MARC A. JUDSON, MILTON D. ROSSMAN, HENRY YEAGER, EDDY A. BRESNITZ, LOUIS DePALO, GARY HUNNINGHAKE, MICHAEL C. IANNUZZI, CAROL J. JOHNS, GEOFFREY McLENNAN, DAVID R. MOLLER, LEE S. NEWMAN, DAVID L. RABIN, CECILE ROSE, BENJAMIN RYBICKI, STEVEN E. WEINBERGER, MICHAEL L. TERRIN, GENELL L. KNATTERUD, REUBEN CHERNIAK, A CASE CONTROL ETIOLOGIC STUDY OF SARCOIDOSIS (ACCESS) RESE GROUP |
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| Rok vydání: | 2001 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male medicine.medical_specialty Systemic disease Sarcoidosis Vital Capacity Black People Critical Care and Intensive Care Medicine Gastroenterology Löfgren syndrome Severity of Illness Index White People Age Distribution Erythema Nodosum Internal medicine Forced Expiratory Volume Severity of illness medicine Humans Sex Distribution Aged Proportional Hazards Models Erythema nodosum Sex Characteristics business.industry Case-control study Age Factors Middle Aged medicine.disease United States Surgery Dyspnea Case-Control Studies Hypercalcemia Linear Models Population study Female business Sex characteristics |
| Zdroj: | American journal of respiratory and critical care medicine. 164(10 Pt 1) |
| ISSN: | 1073-449X |
| Popis: | Sarcoidosis may be affected by sex, race, and age. A Case Control Etiologic Study of Sarcoidosis (ACCESS) enrolled 736 patients with sarcoidosis within 6 mo of diagnosis from 10 clinical centers in the United States. Using the ACCESS sarcoidosis assessment system, we determined organ involvement for the whole group and for subgroups differentiated by sex, race, and age (less than 40 yr or 40 yr and older). The study population was heterogeneous in terms of race (53% white, 44% black), sex (64% female, 36% male), and age (46% or = 40 yr old). Women were more likely to have eye and neurologic involvement (chi(2) = 4.74, p < 0.05 and chi(2) = 4.60, p < 0.05 respectively), have erythema nodosum (chi(2) = 7.28, p < 0.01), and to be age 40 yr or over (chi(2) = 6.07, p < 0.02) whereas men were more likely to be hypercalcemic (chi(2) = 7.38, p < 0.01). Black subjects were more likely to have skin involvement other than erythema nodosum (chi(2) = 5.47, p < 0.05), and eye (chi(2) = 13.8, p < 0.0001), liver (chi(2) = 23.3, p < 0.0001), bone marrow (chi(2) = 18.8, p < 0.001), and extrathoracic lymph node involvement (chi(2) = 7.21, p < 0.01). We conclude that the initial presentation of sarcoidosis is related to sex, race, and age. |
| Databáze: | OpenAIRE |
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