A gel system for single instillation of non-muscle-invasive bladder Cancer: A 'divide-and-rule' strategy
| Autor: | Ziyu Han, Wenting Shang, Jie Tian, Pengyu Guo, Lu Wang, Hongmei Jiang, Wanhai Xu, Kun Wang, Hongzhi Wang, Li Peng |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Dendrimers
medicine.medical_treatment Pharmaceutical Science Mice Nude Antineoplastic Agents 02 engineering and technology Deoxycytidine Polyethylene Glycols 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Drug Delivery Systems medicine Animals Entire bladder Chemotherapy Mice Inbred BALB C Bladder cancer Chemistry Dextrans Photothermal therapy 021001 nanoscience & nanotechnology medicine.disease Tumor site Gemcitabine Dextran Administration Intravesical Urinary Bladder Neoplasms Doxorubicin 030220 oncology & carcinogenesis Cancer research Female 0210 nano-technology Non muscle invasive Gels medicine.drug |
| Zdroj: | Journal of controlled release : official journal of the Controlled Release Society. 285 |
| ISSN: | 1873-4995 |
| Popis: | Single instillation (SI) reduces recurrence of non-muscle-invasive bladder cancer by chemoresecting floating tumor cells and residual tumor lesions (RTLs) after transurethral resection of the bladder, but with limited efficacy. Current studies improved this by prolonging retention time and increasing penetration to bladder wall, ignoring that the two separate factors should be treated in different ways. Here, we introduced a smart gel system-based SI to prevent re-implantation of tumor cells (RTCs) and ablate RTLs in a "divide-and-rule" approach. The gel system was synthesized by PEG-PAMAM and dextran aldehyde and composed of gold nanorods and gemcitabine for photothermal therapy and chemotherapy, respectively. It was developed to provide dextran aldehyde-selective adhesion with tissue amines. Since tumor surface expressed high levels of collagen, the exposed amines could act as adhesion points for the gel system. Thus, the gel presented more affinity to tumor tissues. When being instilled, it could form a protective layer on the inner face of the entire bladder wall immediately, preventing RTCs in early time. And it persisted long at the tumor site, ablating RTLs. Our data proved the gel system improved intravesical treatment efficacy in a "divide-and-rule" approach and might be a promising treatment strategy for SI. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect