Laterality interacts with sex across the schizophrenia/bipolarity continuum: An interpretation of meta-analyses of structural MRI
| Autor: | Steven A. Chance, Timothy J. Crow, Anthony C. James, T H Priddle, Joaquim Radua |
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| Rok vydání: | 2013 |
| Předmět: |
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Psychosis Bipolar Disorder Gyrus Cinguli Hippocampus behavioral disciplines and activities Functional Laterality Gyrus Image Interpretation Computer-Assisted mental disorders Image Processing Computer-Assisted Limbic System medicine Humans Bipolar disorder Biological Psychiatry Cerebral Cortex Sex Characteristics Brain medicine.disease Magnetic Resonance Imaging Uncus Temporal Lobe Psychiatry and Mental health Emotional lateralization medicine.anatomical_structure nervous system Schizophrenia Laterality Parahippocampal Gyrus Female sense organs Psychology Neuroscience Insula Cognitive psychology |
| Zdroj: | Psychiatry Research. 210:1232-1244 |
| ISSN: | 0165-1781 |
| DOI: | 10.1016/j.psychres.2013.07.043 |
| Popis: | Review of the first comprehensive meta-analysis of VBM (voxel-based morphometry) studies in schizophrenia indicates asymmetrical reductions of anterior cingulate gyrus to the right, and medial temporal lobe (including the uncus) and para-hippocampal gyrus to the left. In subsequent meta-analyses of schizophrenia and bipolar disorder change in these limbic structures is systematically related to change in the insula. Deficits in insula (and para-hippocampal gyrus) to the left, and dorsal anterior cingulate gyrus to the right are greater in schizophrenic psychoses whereas deficits in anterior cingulate to the left and insula to the right are greater in bipolar illness. Thus (1) brain structures implicated in schizophrenia include those implicated in bipolar disorder, (2) the variation that separates the prototypical psychoses may be a subset of that relating to the structural asymmetry (the "torque") characteristic of the human brain, and (3) the meta-analysis of Bora et al. (2012) indicates that laterality of involvement of the insula and cingulate gyrus across the spectrum of bipolar and schizophrenic psychoses is critically dependent upon the sex ratio. Thus structural change underlying the continuum of psychosis relates to the interaction of laterality and sex. |
| Databáze: | OpenAIRE |
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