Anti-NR2 antibodies, blood-brain barrier, and cognitive dysfunction

Autor: Philip H. Iffland, Bin Zhang, Damir Janigro, Michael E. Luggen, Gaurav Gulati
Rok vydání: 2016
Předmět:
Adult
Male
medicine.medical_specialty
Traumatic brain injury
Enzyme-Linked Immunosorbent Assay
Context (language use)
S100 Calcium Binding Protein beta Subunit
Blood–brain barrier
Receptors
N-Methyl-D-Aspartate
Severity of Illness Index
Antibodies
03 medical and health sciences
0302 clinical medicine
Rheumatology
Internal medicine
medicine
Humans
Lupus Erythematosus
Systemic
Cognitive Dysfunction
Neuropsychological assessment
Aged
Autoantibodies
030203 arthritis & rheumatology
Systemic lupus erythematosus
medicine.diagnostic_test
biology
business.industry
General Medicine
Middle Aged
medicine.disease
Treatment Outcome
medicine.anatomical_structure
Blood-Brain Barrier
Lupus Coagulation Inhibitor
Immunology
biology.protein
Biomarker (medicine)
Female
Antibody
business
Biomarkers
030217 neurology & neurosurgery
Zdroj: Clinical Rheumatology. 35:2989-2997
ISSN: 1434-9949
0770-3198
Popis: Cognitive dysfunction (CD) is one of the most common neuropsychiatric manifestations of systemic lupus erythematosus (SLE). In animal models, antibodies to NR2 subunit of N-methyl d-aspartate receptor (anti-NR2) cause memory impairment, but only with blood-brain barrier (BBB) disruption or intrathecal administration. Several studies have failed to find association of aNR2 with CD, but none have assessed BBB integrity. S100B, an astrocyte-specific protein, has been used as biomarker of BBB disruption in traumatic brain injury and some neurodegenerative disorders. Antibodies to this immunologically privileged protein (anti-S100B) might indicate preceding BBB disruption. We hypothesized that aNR2 antibody is pathogenic in SLE patients only with BBB disruption. Demographic, clinical, and laboratory data was collected from patients with SLE. Total throughput score (TTS) of the Automated Neuropsychological Assessment Metrics (ANAM) was used as primary outcome measure. CD was defined as TTS
Databáze: OpenAIRE
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