Colorectal Cancer Screening with Computed Tomography Colonography: Single Region Experience in Kazakhstan
| Autor: | Akmaral Ainakulova, Dilyara Kaidarova, Elvira Satbayeva, Alexandra Sergeevna Panina, Madina Orazaykyzy Gabdullina, Nurlan Baltabekov, Marianna Zagurovskaya, Dias Toleshbayev, Zhansaya Kalieva, Jandos Amankulov, Zhamilya Zholdybay |
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| Rok vydání: | 2022 |
| Předmět: |
medicine.medical_specialty
Adenoma Colorectal cancer Medicine (miscellaneous) Colonoscopy RC799-869 Gastroenterology computed tomography colonography colonoscopy Computed Tomography Colonography Internal medicine Cancer screening medicine Radiology Nuclear Medicine and imaging neoplasms medicine.diagnostic_test business.industry Odds ratio colorectal neoplasms Diseases of the digestive system. Gastroenterology medicine.disease RC31-1245 digestive system diseases Confidence interval cancer screening Colorectal cancer screening business |
| Zdroj: | Clinical Endoscopy, Vol 55, Iss 1, Pp 101-112 (2022) |
| ISSN: | 2234-2443 2234-2400 |
| DOI: | 10.5946/ce.2021.066 |
| Popis: | Background/Aims: The aim of our study was to determine the efficacy of computed tomography colonography (CTC) in screening for colorectal cancer (CRC).Methods: A total of 612 females and 588 males aged 45 to 75 years were enrolled in CTC screening. CTC was performed following standard bowel preparation and colonic insufflation with carbon dioxide. The main outcomes were the detection rate of CRC and advanced adenoma (AA), prevalence of colorectal lesions in relation to socio-demographic and health factors, and overall diagnostic performance of CTC.Results: Overall, 56.5% of the 1,200 invited subjects underwent CTC screening. The sensitivity for CRC and AA was 0.89 and 0.97, respectively, while the specificity was 0.71 and 0.99, respectively. The prevalence of CRC and AA was 3.0% (18/593) and 7.1% (42/593), respectively, with the highest CRC prevalence in the 66-75 age group (≥12 times; odds ratio [OR], 12.11; 95% confidence interval [CI], 4.45-32.92). CRC and AA prevalence were inversely correlated with Asian descent, physical activity, and negative fecal immunochemical test results (OR=0.43; 95% CI, 0.22-0.83; OR=0.16; 95% CI, 0.04-0.68; OR=0.5; 95% CI, 0.07-3.85, respectively).Conclusions: Our study revealed high accuracy of CTC in diagnosing colonic neoplasms, good compliance with CTC screening, and high detection rate of CRC. |
| Databáze: | OpenAIRE |
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