Dioxin exposure in breast milk and infant neurodevelopment in Vietnam
| Autor: | Pham The Tai, Muneko Nishijo, Nguyen Thi Nguyet Anh, Shoko Maruzeni, Hideaki Nakagawa, Hoang Van Luong, Tran Hai Anh, Ryumon Honda, Teruhiko Kido, Hisao Nishijo |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Pediatrics medicine.medical_specialty Developmental Disabilities Breastfeeding Physiology Breast milk Dioxins Risk Assessment Bayley Scales of Infant Development Cohort Studies Young Adult Pregnancy Humans Medicine heterocyclic compounds Toddler Maternal-Fetal Exchange Milk Human business.industry Incidence Infant Newborn Public Health Environmental and Occupational Health Infant Environmental Exposure Environmental exposure medicine.disease Breast Feeding Vietnam Maternal Exposure Environmental Pollutants Female Maximum Allowable Concentration business Breast feeding Environmental Monitoring Cohort study |
| Zdroj: | Occupational and Environmental Medicine. 70:656-662 |
| ISSN: | 1470-7926 1351-0711 |
| DOI: | 10.1136/oemed-2012-101021 |
| Popis: | Objectives Dioxin levels in the breast milk of mothers residing near hot spots of dioxin contamination areas in South Vietnam remain much higher than in unsprayed areas, suggesting that fetuses and breast-fed infants may be exposed to high levels of dioxins. The present study investigated the association of infant neurodevelopment in early infancy and dioxin exposure during the perinatal period. Methods The study involved 216 mother-infant pairs living near the Da Nang airbase, a dioxin contaminated area in Vietnam. Mothers and infants were followed from birth until infants were 4 months old. Dioxin levels in breast milk were measured to estimate the perinatal dioxin exposure, including the infant daily dioxin intake (DDI) via breastfeeding. Infant neurodevelopmental parameters, including cognitive, language and motor domains were assessed at approximately 4 months using the Bayley Scales of Infant and Toddler Development, third edition (Bayley-III). Results The level of 2,3,7,8-tetrachlorodibenzo-p-dioxin and polychlorinated dibenzo-p-dioxins/furans-toxic equivalents in breast milk and the infant DDI showed significant inverse correlations with neurodevelopmental scores. When the subjects were divided into four groups according to dioxin levels in breast milk, the moderate and high DDI groups had significantly lower cognitive, composite motor and fine motor scores, and the high polychlorinated dibenzo-p-dioxins/furans-toxic equivalents group had significantly lower fine motor score than the low exposure group. For all domains, neurodevelopmental scores were decreased with increase in the level of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Conclusion The present study demonstrates a considerable impact of perinatal dioxin exposure on neurodevelopment in 4-month-old infants living in contaminated areas in Vietnam. |
| Databáze: | OpenAIRE |
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