In vitro conversion of proinsulin to insulin by cathepsin B in isolated islets and its inhibition by cathepsin B antibodies
| Autor: | Nafees Ahmad, Jalil R. Kidwai, Renu Bansal |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
endocrine system
endocrine system diseases Endocrinology Diabetes and Metabolism Cathepsin D Antibodies Cathepsin B Islets of Langerhans Endocrinology Cathepsin O Cathepsin H Internal Medicine Animals Insulin Proinsulin Cathepsin S chemistry.chemical_classification geography geography.geographical_feature_category Dose-Response Relationship Drug General Medicine Islet Cathepsins Rats Amino acid Biochemistry chemistry Cattle |
| Zdroj: | Acta Diabetologica Latina. 17:255-266 |
| ISSN: | 1432-5233 0001-5563 |
| DOI: | 10.1007/bf02581326 |
| Popis: | Purified bovine cathepsin B, when incubated with isolated rat islets of Langerhans, completely converts proinsulin to insulin as demonstrated by the incorporation of 14C-leucine into islet proteins, releasing lysine as the only basic amino acid. Cathepsin B antibodies raised in rabbit inhibited the above conversion. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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