Left ventricular systolic and diastolic function in normotensive type 2 diabetic patients with or without autonomic neuropathy: a radionuclide ventriculography study
| Autor: | Triantafyllos Didangelos, Theodoros D. Karamitsos, Efstratios Moralidis, Georgios Arsos, Fotios Iliadis, Athanasios A. Papageorgiou, Vasilios G. Athyros |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Cardiac output Systole Diastole Cardiac index Radionuclide ventriculography Ventricular Function Left Coronary artery disease Ventricular Dysfunction Left Diabetic Neuropathies Heart Rate Internal medicine Diabetes mellitus medicine Humans Cardiac Output Radionuclide Ventriculography Diabetic Autonomic Neuropathy Ejection fraction business.industry Patient Selection Middle Aged medicine.disease Cross-Sectional Studies Diabetes Mellitus Type 2 Cardiology Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Angiology. 65(10) |
| ISSN: | 1940-1574 0003-3197 |
| Popis: | We investigated the relation between diabetic autonomic neuropathy (DAN) and left ventricular (LV) function in 59 patients with type 2 diabetes mellitus (T2DM) free of coronary artery disease (CAD) or hypertension. Diabetic autonomic neuropathy was established by ≥2 abnormal autonomic nervous function tests. Left ventricular systolic and diastolic functions were assessed by resting radionuclide ventriculography. Compared with non-DAN patients (n = 24), patients with DAN (n = 35) had an increased adjusted atrial contribution to ventricular filling (A/V%, 30.1% ± 8.2% vs 26.5% ± 5.1%; P = .031), suggestive of diastolic dysfunction (DD). There were no differences between the 2 groups in peak filling rate, first 1/3 filling fraction, ejection fraction, cardiac output, and cardiac index. Patients with diabetic autonomic neuropathy had an increased heart rate (77.8 ± 6.3 vs 69.3 ± 3.3 bpm; P < .0001) and a higher rest LV workload (10 072 ± 1165 vs 8606 ± 1075 bpm mm Hg; P < .0001). Patients with DAN T2DM without CAD or hypertension have DD, increased A/V index, and a higher LV working load than non-DAN patients. |
| Databáze: | OpenAIRE |
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