Differences between paired-pulse facilitation and long-term potentiation in the dorsal and ventral hippocampal CA1-prefrontal pathways of rats
| Autor: | Yoshinori Izaki, Masahiko Nomura, Masatoshi Takita, Tatsuo Akema |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
Long-Term Potentiation Neural facilitation Prefrontal Cortex Hippocampus Neurotransmission Hippocampal formation Synaptic Transmission Neural Pathways LTP induction Animals Rats Wistar Prefrontal cortex Molecular Biology Neuronal Plasticity Chemistry musculoskeletal neural and ocular physiology General Neuroscience Long-term potentiation Electric Stimulation Rats Cortex (botany) nervous system Neurology (clinical) Microelectrodes Neuroscience Developmental Biology |
| Zdroj: | Brain Research. 992:142-145 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/s0006-8993(03)03538-8 |
| Popis: | We studied the interaction between paired-pulse facilitation (PPF) and long-term potentiation (LTP) in the hippocampo-prefrontal cortex (PFC, prelimbic area) pathway, stimulating the ventral or posterior dorsal CA1 region (vCA1 or pdCA1). In the vCA1–PFC, the group averaged PPF did not change after the LTP induction, and there was a negative correlation between the post-LTP PPF change and LTP magnitude. In contrast, the post-LTP PPF of the pdCA1–PFC appeared to decrease significantly, and the PPF change was independent of the LTP magnitude. We found that there were at least two mechanisms of PPF regulation following LTP induction in the pathway resulting from extensive CA1 projections into the prelimbic area. The results imply that the CA1–PFC pathway regulates the PFC PPF quantitatively in LTP-dependent and independent manners, which depend on the local properties of the CA1 regions. |
| Databáze: | OpenAIRE |
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